Mycobacterium tuberculosis in the face of host-imposed nutrient limitation

Michael Berney, Linda Berney-Meyer

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Coevolution of pathogens and host has led to many metabolic strategies employed by intracellular pathogens to deal with the immune response and the scarcity of food during infection. Simply put, bacterial pathogens are just looking for food. As a consequence, the host has developed strategies to limit nutrients for the bacterium by containment of the intruder in a pathogen-containing vacuole and/or by actively depleting nutrients from the intracellular space, a process called nutritional immunity. Since metabolism is a prerequisite for virulence, such pathways could potentially be good targets for antimicrobial therapies. In this chapter, we review the current knowledge about the in vivo diet of Mycobacterium tuberculosis, with a focus on amino acid and cofactors, discuss evidence for the bacilli's nutritionally independent lifestyle in the host, and evaluate strategies for new chemotherapeutic interventions.

Original languageEnglish (US)
Article numberTBTB2-0030-2016
JournalMicrobiology spectrum
Volume5
Issue number3
DOIs
StatePublished - Jun 1 2017

Fingerprint

tuberculosis
nutrient limitation
Mycobacterium tuberculosis
pathogen
Food
Nutritional Physiological Phenomena
Intracellular Space
food
nutrient
coevolution
immunity
containment
Vacuoles
virulence
immune response
lifestyle
Bacillus
Virulence
Life Style
Immunity

ASJC Scopus subject areas

  • Physiology
  • Ecology
  • Immunology and Microbiology(all)
  • Genetics
  • Cell Biology
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Mycobacterium tuberculosis in the face of host-imposed nutrient limitation. / Berney, Michael; Berney-Meyer, Linda.

In: Microbiology spectrum, Vol. 5, No. 3, TBTB2-0030-2016, 01.06.2017.

Research output: Contribution to journalArticle

@article{bde5a5ec005a4308bdb9669eff82061c,
title = "Mycobacterium tuberculosis in the face of host-imposed nutrient limitation",
abstract = "Coevolution of pathogens and host has led to many metabolic strategies employed by intracellular pathogens to deal with the immune response and the scarcity of food during infection. Simply put, bacterial pathogens are just looking for food. As a consequence, the host has developed strategies to limit nutrients for the bacterium by containment of the intruder in a pathogen-containing vacuole and/or by actively depleting nutrients from the intracellular space, a process called nutritional immunity. Since metabolism is a prerequisite for virulence, such pathways could potentially be good targets for antimicrobial therapies. In this chapter, we review the current knowledge about the in vivo diet of Mycobacterium tuberculosis, with a focus on amino acid and cofactors, discuss evidence for the bacilli's nutritionally independent lifestyle in the host, and evaluate strategies for new chemotherapeutic interventions.",
author = "Michael Berney and Linda Berney-Meyer",
year = "2017",
month = "6",
day = "1",
doi = "10.1128/microbiolspec.TBTB2-0030-2016",
language = "English (US)",
volume = "5",
journal = "Microbiology spectrum",
issn = "2165-0497",
publisher = "American Society for Microbiology",
number = "3",

}

TY - JOUR

T1 - Mycobacterium tuberculosis in the face of host-imposed nutrient limitation

AU - Berney, Michael

AU - Berney-Meyer, Linda

PY - 2017/6/1

Y1 - 2017/6/1

N2 - Coevolution of pathogens and host has led to many metabolic strategies employed by intracellular pathogens to deal with the immune response and the scarcity of food during infection. Simply put, bacterial pathogens are just looking for food. As a consequence, the host has developed strategies to limit nutrients for the bacterium by containment of the intruder in a pathogen-containing vacuole and/or by actively depleting nutrients from the intracellular space, a process called nutritional immunity. Since metabolism is a prerequisite for virulence, such pathways could potentially be good targets for antimicrobial therapies. In this chapter, we review the current knowledge about the in vivo diet of Mycobacterium tuberculosis, with a focus on amino acid and cofactors, discuss evidence for the bacilli's nutritionally independent lifestyle in the host, and evaluate strategies for new chemotherapeutic interventions.

AB - Coevolution of pathogens and host has led to many metabolic strategies employed by intracellular pathogens to deal with the immune response and the scarcity of food during infection. Simply put, bacterial pathogens are just looking for food. As a consequence, the host has developed strategies to limit nutrients for the bacterium by containment of the intruder in a pathogen-containing vacuole and/or by actively depleting nutrients from the intracellular space, a process called nutritional immunity. Since metabolism is a prerequisite for virulence, such pathways could potentially be good targets for antimicrobial therapies. In this chapter, we review the current knowledge about the in vivo diet of Mycobacterium tuberculosis, with a focus on amino acid and cofactors, discuss evidence for the bacilli's nutritionally independent lifestyle in the host, and evaluate strategies for new chemotherapeutic interventions.

UR - http://www.scopus.com/inward/record.url?scp=85020286726&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85020286726&partnerID=8YFLogxK

U2 - 10.1128/microbiolspec.TBTB2-0030-2016

DO - 10.1128/microbiolspec.TBTB2-0030-2016

M3 - Article

C2 - 28597811

AN - SCOPUS:85020286726

VL - 5

JO - Microbiology spectrum

JF - Microbiology spectrum

SN - 2165-0497

IS - 3

M1 - TBTB2-0030-2016

ER -