TY - JOUR
T1 - Mycobacterium tuberculosis in the face of host-imposed nutrient limitation
AU - Berney, Michael
AU - Berney-Meyer, Linda
N1 - Publisher Copyright:
© 2017 American Society for Microbiology. All rights reserved.
PY - 2017/6/1
Y1 - 2017/6/1
N2 - Coevolution of pathogens and host has led to many metabolic strategies employed by intracellular pathogens to deal with the immune response and the scarcity of food during infection. Simply put, bacterial pathogens are just looking for food. As a consequence, the host has developed strategies to limit nutrients for the bacterium by containment of the intruder in a pathogen-containing vacuole and/or by actively depleting nutrients from the intracellular space, a process called nutritional immunity. Since metabolism is a prerequisite for virulence, such pathways could potentially be good targets for antimicrobial therapies. In this chapter, we review the current knowledge about the in vivo diet of Mycobacterium tuberculosis, with a focus on amino acid and cofactors, discuss evidence for the bacilli's nutritionally independent lifestyle in the host, and evaluate strategies for new chemotherapeutic interventions.
AB - Coevolution of pathogens and host has led to many metabolic strategies employed by intracellular pathogens to deal with the immune response and the scarcity of food during infection. Simply put, bacterial pathogens are just looking for food. As a consequence, the host has developed strategies to limit nutrients for the bacterium by containment of the intruder in a pathogen-containing vacuole and/or by actively depleting nutrients from the intracellular space, a process called nutritional immunity. Since metabolism is a prerequisite for virulence, such pathways could potentially be good targets for antimicrobial therapies. In this chapter, we review the current knowledge about the in vivo diet of Mycobacterium tuberculosis, with a focus on amino acid and cofactors, discuss evidence for the bacilli's nutritionally independent lifestyle in the host, and evaluate strategies for new chemotherapeutic interventions.
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U2 - 10.1128/microbiolspec.TBTB2-0030-2016
DO - 10.1128/microbiolspec.TBTB2-0030-2016
M3 - Article
C2 - 28597811
AN - SCOPUS:85020286726
SN - 2165-0497
VL - 5
JO - Microbiology Spectrum
JF - Microbiology Spectrum
IS - 3
M1 - TBTB2-0030-2016
ER -