Mycobacterium avium complex-associated cholecystitis in AIDS patient: a case description and review of literature

Firas El Chaer, Nadine Harris, Hana El Sahly, Vagish S. Hemmige, Elvia Martinez Blanco, Laila Woc-Colburn

Research output: Contribution to journalArticle

Abstract

AIDS-related cholangiopathy was common in patients with AIDS prior to the advent of highly active antiretroviral therapy. Mycobacterium avium complex (MAC) is the most common opportunistic bacterial infection seen in AIDS patients and one of many opportunistic pathogens implicated in AIDS cholangiopathy. We describe a case of acute cholecystitis secondary to MAC in a patient with likely AIDS cholangiopathy. The patient, a 37-year-old Hispanic woman with CD4+ cell count of 10 cells/mm3 who was previously diagnosed with disseminated MAC, presented with a eight days of diffuse abdominal pain and anorexia. Radiologic imaging suggested acute cholecystitis, so the patient underwent open cholecystectomy. Pathology staining of the gall bladder wall revealed acid-fast bacilli consistent with MAC. The patient had been receiving appropriate therapy as an outpatient for MAC with presumed reliable adherence, but we suggest her burden of disease was high due to her severe immunosuppressive state. A thorough review of the literature showed that there are many infectious and non-infectious aetiologies for AIDS-associated cholangiopathy. Acute cholecystitis can develop in the setting of AIDS cholangiopathy, potentially secondary to the opportunistic infection that initially caused the cholangiopathy. MAC-related gallbladder disease needs to be considered in patients with advanced AIDS who present with evidence of acute cholecystitis.

Original languageEnglish (US)
Pages (from-to)1218-1222
Number of pages5
JournalInternational Journal of STD and AIDS
Volume27
Issue number13
DOIs
StatePublished - Nov 1 2016
Externally publishedYes

Fingerprint

Mycobacterium avium Complex
Cholecystitis
Acquired Immunodeficiency Syndrome
Acute Cholecystitis
Opportunistic Infections
Gallbladder Diseases
Highly Active Antiretroviral Therapy
Anorexia
Cholecystectomy
Immunosuppressive Agents
CD4 Lymphocyte Count
Hispanic Americans
Bacterial Infections
Bacillus
Abdominal Pain
Urinary Bladder
Outpatients
Pathology
Staining and Labeling
Acids

Keywords

  • AIDS cholangiopathy
  • HIV/AIDS
  • Mycobacterium avium complex cholecystitis

ASJC Scopus subject areas

  • Dermatology
  • Public Health, Environmental and Occupational Health
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Mycobacterium avium complex-associated cholecystitis in AIDS patient : a case description and review of literature. / El Chaer, Firas; Harris, Nadine; El Sahly, Hana; Hemmige, Vagish S.; Martinez Blanco, Elvia; Woc-Colburn, Laila.

In: International Journal of STD and AIDS, Vol. 27, No. 13, 01.11.2016, p. 1218-1222.

Research output: Contribution to journalArticle

El Chaer, Firas ; Harris, Nadine ; El Sahly, Hana ; Hemmige, Vagish S. ; Martinez Blanco, Elvia ; Woc-Colburn, Laila. / Mycobacterium avium complex-associated cholecystitis in AIDS patient : a case description and review of literature. In: International Journal of STD and AIDS. 2016 ; Vol. 27, No. 13. pp. 1218-1222.
@article{6e85abd575df40a89d909ecf39fcb089,
title = "Mycobacterium avium complex-associated cholecystitis in AIDS patient: a case description and review of literature",
abstract = "AIDS-related cholangiopathy was common in patients with AIDS prior to the advent of highly active antiretroviral therapy. Mycobacterium avium complex (MAC) is the most common opportunistic bacterial infection seen in AIDS patients and one of many opportunistic pathogens implicated in AIDS cholangiopathy. We describe a case of acute cholecystitis secondary to MAC in a patient with likely AIDS cholangiopathy. The patient, a 37-year-old Hispanic woman with CD4+ cell count of 10 cells/mm3 who was previously diagnosed with disseminated MAC, presented with a eight days of diffuse abdominal pain and anorexia. Radiologic imaging suggested acute cholecystitis, so the patient underwent open cholecystectomy. Pathology staining of the gall bladder wall revealed acid-fast bacilli consistent with MAC. The patient had been receiving appropriate therapy as an outpatient for MAC with presumed reliable adherence, but we suggest her burden of disease was high due to her severe immunosuppressive state. A thorough review of the literature showed that there are many infectious and non-infectious aetiologies for AIDS-associated cholangiopathy. Acute cholecystitis can develop in the setting of AIDS cholangiopathy, potentially secondary to the opportunistic infection that initially caused the cholangiopathy. MAC-related gallbladder disease needs to be considered in patients with advanced AIDS who present with evidence of acute cholecystitis.",
keywords = "AIDS cholangiopathy, HIV/AIDS, Mycobacterium avium complex cholecystitis",
author = "{El Chaer}, Firas and Nadine Harris and {El Sahly}, Hana and Hemmige, {Vagish S.} and {Martinez Blanco}, Elvia and Laila Woc-Colburn",
year = "2016",
month = "11",
day = "1",
doi = "10.1177/0956462415588445",
language = "English (US)",
volume = "27",
pages = "1218--1222",
journal = "International Journal of STD and AIDS",
issn = "0956-4624",
publisher = "SAGE Publications Ltd",
number = "13",

}

TY - JOUR

T1 - Mycobacterium avium complex-associated cholecystitis in AIDS patient

T2 - a case description and review of literature

AU - El Chaer, Firas

AU - Harris, Nadine

AU - El Sahly, Hana

AU - Hemmige, Vagish S.

AU - Martinez Blanco, Elvia

AU - Woc-Colburn, Laila

PY - 2016/11/1

Y1 - 2016/11/1

N2 - AIDS-related cholangiopathy was common in patients with AIDS prior to the advent of highly active antiretroviral therapy. Mycobacterium avium complex (MAC) is the most common opportunistic bacterial infection seen in AIDS patients and one of many opportunistic pathogens implicated in AIDS cholangiopathy. We describe a case of acute cholecystitis secondary to MAC in a patient with likely AIDS cholangiopathy. The patient, a 37-year-old Hispanic woman with CD4+ cell count of 10 cells/mm3 who was previously diagnosed with disseminated MAC, presented with a eight days of diffuse abdominal pain and anorexia. Radiologic imaging suggested acute cholecystitis, so the patient underwent open cholecystectomy. Pathology staining of the gall bladder wall revealed acid-fast bacilli consistent with MAC. The patient had been receiving appropriate therapy as an outpatient for MAC with presumed reliable adherence, but we suggest her burden of disease was high due to her severe immunosuppressive state. A thorough review of the literature showed that there are many infectious and non-infectious aetiologies for AIDS-associated cholangiopathy. Acute cholecystitis can develop in the setting of AIDS cholangiopathy, potentially secondary to the opportunistic infection that initially caused the cholangiopathy. MAC-related gallbladder disease needs to be considered in patients with advanced AIDS who present with evidence of acute cholecystitis.

AB - AIDS-related cholangiopathy was common in patients with AIDS prior to the advent of highly active antiretroviral therapy. Mycobacterium avium complex (MAC) is the most common opportunistic bacterial infection seen in AIDS patients and one of many opportunistic pathogens implicated in AIDS cholangiopathy. We describe a case of acute cholecystitis secondary to MAC in a patient with likely AIDS cholangiopathy. The patient, a 37-year-old Hispanic woman with CD4+ cell count of 10 cells/mm3 who was previously diagnosed with disseminated MAC, presented with a eight days of diffuse abdominal pain and anorexia. Radiologic imaging suggested acute cholecystitis, so the patient underwent open cholecystectomy. Pathology staining of the gall bladder wall revealed acid-fast bacilli consistent with MAC. The patient had been receiving appropriate therapy as an outpatient for MAC with presumed reliable adherence, but we suggest her burden of disease was high due to her severe immunosuppressive state. A thorough review of the literature showed that there are many infectious and non-infectious aetiologies for AIDS-associated cholangiopathy. Acute cholecystitis can develop in the setting of AIDS cholangiopathy, potentially secondary to the opportunistic infection that initially caused the cholangiopathy. MAC-related gallbladder disease needs to be considered in patients with advanced AIDS who present with evidence of acute cholecystitis.

KW - AIDS cholangiopathy

KW - HIV/AIDS

KW - Mycobacterium avium complex cholecystitis

UR - http://www.scopus.com/inward/record.url?scp=84992688650&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84992688650&partnerID=8YFLogxK

U2 - 10.1177/0956462415588445

DO - 10.1177/0956462415588445

M3 - Article

C2 - 26023092

AN - SCOPUS:84992688650

VL - 27

SP - 1218

EP - 1222

JO - International Journal of STD and AIDS

JF - International Journal of STD and AIDS

SN - 0956-4624

IS - 13

ER -