Mycobacterial shikimate pathway enzymes as targets for drug design

Rodrigo G. Ducati, Luiz A. Basso, Diogenes S. Santos

Research output: Contribution to journalReview article

57 Citations (Scopus)

Abstract

The aetiological agent of tuberculosis (TB), Mycobacterium tuberculosis, is responsible for millions of deaths annually. The increasing prevalence of the disease, the emergence of multidrug-resistant strains, and the devastating effect of human immunodeficiency virus co-infection have led to an urgent need for the development of new and more efficient antimycobacterial drugs. Since the shikimate pathway is present and essential in algae, higher plants, bacteria, and fungi, but absent from mammals, the gene products of the common pathway might represent attractive targets for the development of new antimycobacterial agents. In this review we describe studies on shikimate pathway enzymes, including enzyme kinetics and structural data. We have focused on mycobacterial shikimate pathway enzymes as potential targets for the development of new anti-TB agents.

Original languageEnglish (US)
Pages (from-to)423-435
Number of pages13
JournalCurrent Drug Targets
Volume8
Issue number3
DOIs
StatePublished - Mar 2007
Externally publishedYes

Fingerprint

Drug Design
Enzyme kinetics
Mammals
Tuberculosis
Enzymes
Algae
Fungi
Viruses
Pharmaceutical Preparations
Bacteria
Genes
Virus Diseases
Anti-Bacterial Agents
Coinfection
Mycobacterium tuberculosis
HIV

Keywords

  • 3-dehydroquinate dehydratase
  • 3-dehydroquinate synthase
  • 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase
  • 5-enolpyruvylshikimate-3-phosphate synthase
  • Antimycobacterialdrug design
  • Chorismate synthase
  • Shikimate 5-dehydrogenase
  • Shikimate kinase

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmaceutical Science

Cite this

Mycobacterial shikimate pathway enzymes as targets for drug design. / Ducati, Rodrigo G.; Basso, Luiz A.; Santos, Diogenes S.

In: Current Drug Targets, Vol. 8, No. 3, 03.2007, p. 423-435.

Research output: Contribution to journalReview article

Ducati, Rodrigo G. ; Basso, Luiz A. ; Santos, Diogenes S. / Mycobacterial shikimate pathway enzymes as targets for drug design. In: Current Drug Targets. 2007 ; Vol. 8, No. 3. pp. 423-435.
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