Mutual interactions between repeated flurothyl convulsions and electrical kindling

Bowen Y. Wong, Solomon L. Moshe

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The interactions between repeated flurothyl seizures and electrical kindling induced from the neocortex or the amygdala were investigated. Three consecutive flurothyl-induced convulsions enhanced the rate of development of subsequent electrical kindling from the neocortex. Similarly multiple (more than 15) generalized kindled seizures, induced from either the neocortex or the amygdala, reduced the latency of onset of flurothyl seizures with repeated exposures producing a 'kindling-like' effect for flurothyl. These results indicate that eventually seizures will beget seizures independently of the site of origination of the seizures.

Original languageEnglish (US)
Pages (from-to)159-164
Number of pages6
JournalEpilepsy Research
Volume1
Issue number3
DOIs
StatePublished - 1987

Fingerprint

Flurothyl
Seizures
Neocortex
Amygdala

Keywords

  • Convulsions
  • Flurothyl
  • Kindling
  • Rats
  • Seizures
  • Transfer

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Neurology

Cite this

Mutual interactions between repeated flurothyl convulsions and electrical kindling. / Wong, Bowen Y.; Moshe, Solomon L.

In: Epilepsy Research, Vol. 1, No. 3, 1987, p. 159-164.

Research output: Contribution to journalArticle

@article{cc246bd775ff4b0abe0bf9c9ae8eb240,
title = "Mutual interactions between repeated flurothyl convulsions and electrical kindling",
abstract = "The interactions between repeated flurothyl seizures and electrical kindling induced from the neocortex or the amygdala were investigated. Three consecutive flurothyl-induced convulsions enhanced the rate of development of subsequent electrical kindling from the neocortex. Similarly multiple (more than 15) generalized kindled seizures, induced from either the neocortex or the amygdala, reduced the latency of onset of flurothyl seizures with repeated exposures producing a 'kindling-like' effect for flurothyl. These results indicate that eventually seizures will beget seizures independently of the site of origination of the seizures.",
keywords = "Convulsions, Flurothyl, Kindling, Rats, Seizures, Transfer",
author = "Wong, {Bowen Y.} and Moshe, {Solomon L.}",
year = "1987",
doi = "10.1016/0920-1211(87)90036-2",
language = "English (US)",
volume = "1",
pages = "159--164",
journal = "Epilepsy Research",
issn = "0920-1211",
publisher = "Elsevier",
number = "3",

}

TY - JOUR

T1 - Mutual interactions between repeated flurothyl convulsions and electrical kindling

AU - Wong, Bowen Y.

AU - Moshe, Solomon L.

PY - 1987

Y1 - 1987

N2 - The interactions between repeated flurothyl seizures and electrical kindling induced from the neocortex or the amygdala were investigated. Three consecutive flurothyl-induced convulsions enhanced the rate of development of subsequent electrical kindling from the neocortex. Similarly multiple (more than 15) generalized kindled seizures, induced from either the neocortex or the amygdala, reduced the latency of onset of flurothyl seizures with repeated exposures producing a 'kindling-like' effect for flurothyl. These results indicate that eventually seizures will beget seizures independently of the site of origination of the seizures.

AB - The interactions between repeated flurothyl seizures and electrical kindling induced from the neocortex or the amygdala were investigated. Three consecutive flurothyl-induced convulsions enhanced the rate of development of subsequent electrical kindling from the neocortex. Similarly multiple (more than 15) generalized kindled seizures, induced from either the neocortex or the amygdala, reduced the latency of onset of flurothyl seizures with repeated exposures producing a 'kindling-like' effect for flurothyl. These results indicate that eventually seizures will beget seizures independently of the site of origination of the seizures.

KW - Convulsions

KW - Flurothyl

KW - Kindling

KW - Rats

KW - Seizures

KW - Transfer

UR - http://www.scopus.com/inward/record.url?scp=0023583159&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023583159&partnerID=8YFLogxK

U2 - 10.1016/0920-1211(87)90036-2

DO - 10.1016/0920-1211(87)90036-2

M3 - Article

VL - 1

SP - 159

EP - 164

JO - Epilepsy Research

JF - Epilepsy Research

SN - 0920-1211

IS - 3

ER -