Mutual interactions between repeated flurothyl convulsions and electrical kindling

Bowen Y. Wong, Solomon L. Moshé

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

The interactions between repeated flurothyl seizures and electrical kindling induced from the neocortex or the amygdala were investigated. Three consecutive flurothyl-induced convulsions enhanced the rate of development of subsequent electrical kindling from the neocortex. Similarly multiple (more than 15) generalized kindled seizures, induced from either the neocortex or the amygdala, reduced the latency of onset of flurothyl seizures with repeated exposures producing a 'kindling-like' effect for flurothyl. These results indicate that eventually seizures will beget seizures independently of the site of origination of the seizures.

Original languageEnglish (US)
Pages (from-to)159-164
Number of pages6
JournalEpilepsy Research
Volume1
Issue number3
DOIs
Publication statusPublished - May 1987

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Keywords

  • Convulsions
  • Flurothyl
  • Kindling
  • Rats
  • Seizures
  • Transfer

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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