Mutations proximal to the minor groove-binding track of human immunodeficiency virus type 1 reverse transcriptase differentially affect utilization of RNA versus DNA as template

Medicine & Life Sciences

• Human immunodeficiency virus 1 reverse transcriptase 100%
• HIV-1 63%
• RNA 50%
• Mutation 40%
• DNA 40%
• Hydrogen Bonding 14%
• RNA-Directed DNA Polymerase 14%
• Thumb 13%
• DNA-Directed DNA Polymerase 13%
• Molecular Dynamics Simulation 13%
• Enzymes 13%
• Polymerization 12%

Agriculture & Biology

• Human immunodeficiency virus 1 89%
• mutation 49%
• RNA 48%
• DNA 36%
• synthesis 19%
• molecular dynamics 15%
• hydrogen bonding 14%
• DNA-directed DNA polymerase 13%
• polymerization 11%
• enzymes 10%