Mutations on the second chromosome affecting the drosophila Eye

Nicholas E. Baker, Kevin Moses, Donna Nakahara, Michael C. Ellis, Richard W. Carthew, Gerald M. Rubin

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

In the developing eye of Drosophila, cell interactions appear to be responsible for organising undifferentiated cells into unit eyes, or ommatidia. Extensive mutagenesis has been used to search for mutations affecting the development and differentiation of ommatidia. These mutations have been characterized using sections of adults and immunocytochemistry of imaginal discs. Fourteen loci on the second chromosome are described that affect the spacing of the preclusters, the differentiation of ommatidial cells, orientation of the ommatidia, or architecture of the adult retina, that cause retinal degeneration in larval or pupal eye discs, or that cause homeotic transformation of part of the head.

Original languageEnglish (US)
Pages (from-to)85-100
Number of pages16
JournalJournal of Neurogenetics
Volume8
Issue number2
DOIs
StatePublished - 1992
Externally publishedYes

Fingerprint

Drosophila
Chromosomes
Mutation
Imaginal Discs
Retinal Degeneration
Cell Communication
Mutagenesis
Retina
Cell Differentiation
Immunohistochemistry
Head

Keywords

  • Cell interactions
  • Drosophila eye
  • Genetic screen
  • Pattern formation

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Genetics
  • Developmental Biology
  • Neuroscience(all)

Cite this

Baker, N. E., Moses, K., Nakahara, D., Ellis, M. C., Carthew, R. W., & Rubin, G. M. (1992). Mutations on the second chromosome affecting the drosophila Eye. Journal of Neurogenetics, 8(2), 85-100. https://doi.org/10.3109/01677069209084154

Mutations on the second chromosome affecting the drosophila Eye. / Baker, Nicholas E.; Moses, Kevin; Nakahara, Donna; Ellis, Michael C.; Carthew, Richard W.; Rubin, Gerald M.

In: Journal of Neurogenetics, Vol. 8, No. 2, 1992, p. 85-100.

Research output: Contribution to journalArticle

Baker, NE, Moses, K, Nakahara, D, Ellis, MC, Carthew, RW & Rubin, GM 1992, 'Mutations on the second chromosome affecting the drosophila Eye', Journal of Neurogenetics, vol. 8, no. 2, pp. 85-100. https://doi.org/10.3109/01677069209084154
Baker, Nicholas E. ; Moses, Kevin ; Nakahara, Donna ; Ellis, Michael C. ; Carthew, Richard W. ; Rubin, Gerald M. / Mutations on the second chromosome affecting the drosophila Eye. In: Journal of Neurogenetics. 1992 ; Vol. 8, No. 2. pp. 85-100.
@article{94e59a2813524f2ba23c8fdd38c2ff02,
title = "Mutations on the second chromosome affecting the drosophila Eye",
abstract = "In the developing eye of Drosophila, cell interactions appear to be responsible for organising undifferentiated cells into unit eyes, or ommatidia. Extensive mutagenesis has been used to search for mutations affecting the development and differentiation of ommatidia. These mutations have been characterized using sections of adults and immunocytochemistry of imaginal discs. Fourteen loci on the second chromosome are described that affect the spacing of the preclusters, the differentiation of ommatidial cells, orientation of the ommatidia, or architecture of the adult retina, that cause retinal degeneration in larval or pupal eye discs, or that cause homeotic transformation of part of the head.",
keywords = "Cell interactions, Drosophila eye, Genetic screen, Pattern formation",
author = "Baker, {Nicholas E.} and Kevin Moses and Donna Nakahara and Ellis, {Michael C.} and Carthew, {Richard W.} and Rubin, {Gerald M.}",
year = "1992",
doi = "10.3109/01677069209084154",
language = "English (US)",
volume = "8",
pages = "85--100",
journal = "Journal of Neurogenetics",
issn = "0167-7063",
publisher = "Informa Healthcare",
number = "2",

}

TY - JOUR

T1 - Mutations on the second chromosome affecting the drosophila Eye

AU - Baker, Nicholas E.

AU - Moses, Kevin

AU - Nakahara, Donna

AU - Ellis, Michael C.

AU - Carthew, Richard W.

AU - Rubin, Gerald M.

PY - 1992

Y1 - 1992

N2 - In the developing eye of Drosophila, cell interactions appear to be responsible for organising undifferentiated cells into unit eyes, or ommatidia. Extensive mutagenesis has been used to search for mutations affecting the development and differentiation of ommatidia. These mutations have been characterized using sections of adults and immunocytochemistry of imaginal discs. Fourteen loci on the second chromosome are described that affect the spacing of the preclusters, the differentiation of ommatidial cells, orientation of the ommatidia, or architecture of the adult retina, that cause retinal degeneration in larval or pupal eye discs, or that cause homeotic transformation of part of the head.

AB - In the developing eye of Drosophila, cell interactions appear to be responsible for organising undifferentiated cells into unit eyes, or ommatidia. Extensive mutagenesis has been used to search for mutations affecting the development and differentiation of ommatidia. These mutations have been characterized using sections of adults and immunocytochemistry of imaginal discs. Fourteen loci on the second chromosome are described that affect the spacing of the preclusters, the differentiation of ommatidial cells, orientation of the ommatidia, or architecture of the adult retina, that cause retinal degeneration in larval or pupal eye discs, or that cause homeotic transformation of part of the head.

KW - Cell interactions

KW - Drosophila eye

KW - Genetic screen

KW - Pattern formation

UR - http://www.scopus.com/inward/record.url?scp=0026863168&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026863168&partnerID=8YFLogxK

U2 - 10.3109/01677069209084154

DO - 10.3109/01677069209084154

M3 - Article

VL - 8

SP - 85

EP - 100

JO - Journal of Neurogenetics

JF - Journal of Neurogenetics

SN - 0167-7063

IS - 2

ER -