Mutations in ribosomal proteins: Apoptosis, cell competition, and cancer

Nicholas E. Baker, Abhijit Kale

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Mutations affecting multiple ribosomal proteins are implicated in cancer. Using genetic mosaics in the fruit fly Drosophila, we describe 3 apoptotic mechanisms that affect Rp/Rp homozygous mutant cells, Rp/+ heterozygous cells, or Rp/+ heterozygous cells in competition with nearby wild type cells, and discuss how apoptosis might be related to cancer predisposition.

Original languageEnglish (US)
Article numbere1029065
JournalMolecular and Cellular Oncology
Volume3
Issue number1
DOIs
StatePublished - Jan 2 2016

Keywords

  • Drosophila melanogaster
  • apoptosis
  • cancer predisposition
  • genetic mosaic
  • ribosomal protein
  • somatic mutation

ASJC Scopus subject areas

  • Molecular Medicine
  • Cancer Research

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