Mutations in PFCRT K76T do not correlate with sulfadoxine-pyrimethamine- amodiaquine failure in Pikine, Senegal

Ousmane Sarr, Ambroise D. Ahouidi, Omar Ly, Johanna P. Daily, Daouda Ndiaye, Omar Ndir, Souleymane Mboup, Dyann F. Wirth

Research output: Contribution to journalArticle

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Abstract

In 2003, the high level of chloroquine (CQ) treatment failure for uncomplicated Plasmodium falciparum malaria cases has led Senegal to adopt a new combination therapy with sulfadoxine-pyrimethamine and amodiaquine (SP-AQ). From September through November 2004, we used the 14-day World Health Organization follow-up protocol to assess the therapeutic response in patients with uncomplicated P. falciparum malaria in an area of high prevalence of pfcrt T76 mutant allele and SP resistance mutations. Of the 82 patients who were recruited, 68 (82.9%) completed follow-up. The response of the patients to treatment was adequate clinical response for 63 out of 68 patients (92.6%), while five (7.4%) clinical failures were recorded, four early treatment failures, and one late treatment failure. The prevalence of the pfcrt T76 allele at day 0 was 59.5%. The two-sided Fisher's exact test did not show an association between pfcrt T76 allele and treatment failure (p=0.167). The transitory treatment is effective and safe. However, the presence of high levels of mutant alleles points out the need to closely monitor the new therapeutic regimen.

Original languageEnglish (US)
Pages (from-to)765-769
Number of pages5
JournalParasitology Research
Volume103
Issue number4
DOIs
StatePublished - Sep 2008
Externally publishedYes

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sulfadoxine
Amodiaquine
pyrimethamine
Senegal
Treatment Failure
alleles
mutation
Mutation
Alleles
Plasmodium falciparum
malaria
therapeutics
Falciparum Malaria
chloroquine
mutants
World Health Organization
Therapeutics
new combination
Chloroquine
pyrimethamine drug combination fanasil

ASJC Scopus subject areas

  • Parasitology

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Mutations in PFCRT K76T do not correlate with sulfadoxine-pyrimethamine- amodiaquine failure in Pikine, Senegal. / Sarr, Ousmane; Ahouidi, Ambroise D.; Ly, Omar; Daily, Johanna P.; Ndiaye, Daouda; Ndir, Omar; Mboup, Souleymane; Wirth, Dyann F.

In: Parasitology Research, Vol. 103, No. 4, 09.2008, p. 765-769.

Research output: Contribution to journalArticle

Sarr, Ousmane ; Ahouidi, Ambroise D. ; Ly, Omar ; Daily, Johanna P. ; Ndiaye, Daouda ; Ndir, Omar ; Mboup, Souleymane ; Wirth, Dyann F. / Mutations in PFCRT K76T do not correlate with sulfadoxine-pyrimethamine- amodiaquine failure in Pikine, Senegal. In: Parasitology Research. 2008 ; Vol. 103, No. 4. pp. 765-769.
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