Mutant monoclonal antibodies with alterations in biological functions

D. E. Yelton, Matthew D. Scharff

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Somatic cell mutants with deletions in the immunoglobulin constant region were isolated from an IgG(2b) Ar-binding hybridoma. Rat anti-mouse immunoglobulins were used to identify the sites of the deletions. The mutant monoclonal antibodies differ from the parental molecule in their assembly states and are defective in various immunoglobulin activities, making them potentially more useful reagents.

Original languageEnglish (US)
Pages (from-to)1131-1148
Number of pages18
JournalJournal of Experimental Medicine
Volume156
Issue number4
StatePublished - 1982

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Immunoglobulins
Immunoglobulin Constant Regions
Monoclonal Antibodies
Hybridomas
Immunoglobulin G

ASJC Scopus subject areas

  • Immunology

Cite this

Mutant monoclonal antibodies with alterations in biological functions. / Yelton, D. E.; Scharff, Matthew D.

In: Journal of Experimental Medicine, Vol. 156, No. 4, 1982, p. 1131-1148.

Research output: Contribution to journalArticle

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