Mutagenesis of mouse myeloma cells with 'Melphalan'

Jean Louis Preud'homme, Joel Buxbaum, Matthew D. Scharff

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

TAYLOR et al. reported regression of ascites and solid tumours in mice inoculated with bovine enterovirus 1 (BEV-1)1 without any observable pathological effect on the animals. The basis of the oncolytic specificity was associated with the adsorption spectrum of the virus 2,3. The specificity was also expressed in vitro since virus transformed and oncogenic cells were susceptible to BEV-1, in contrast to cells of un-transformed lines and of primary cultures, which were resistant 4.

Original languageEnglish (US)
Pages (from-to)320-322
Number of pages3
JournalNature
Volume245
Issue number5424
DOIs
StatePublished - 1973

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Bovine Enterovirus
Melphalan
Mutagenesis
Oncogenic Viruses
Transformed Cell Line
Ascites
Adsorption
Viruses
Neoplasms

ASJC Scopus subject areas

  • General

Cite this

Mutagenesis of mouse myeloma cells with 'Melphalan'. / Preud'homme, Jean Louis; Buxbaum, Joel; Scharff, Matthew D.

In: Nature, Vol. 245, No. 5424, 1973, p. 320-322.

Research output: Contribution to journalArticle

Preud'homme, JL, Buxbaum, J & Scharff, MD 1973, 'Mutagenesis of mouse myeloma cells with 'Melphalan'', Nature, vol. 245, no. 5424, pp. 320-322. https://doi.org/10.1038/245320a0
Preud'homme, Jean Louis ; Buxbaum, Joel ; Scharff, Matthew D. / Mutagenesis of mouse myeloma cells with 'Melphalan'. In: Nature. 1973 ; Vol. 245, No. 5424. pp. 320-322.
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