Mutagenesis of mouse myeloma cells with 'Melphalan'

TAYLOR et al. reported regression of ascites and solid tumours in mice inoculated with bovine enterovirus ¹ (BEV-1)¹ without any observable pathological effect on the animals. The basis of the oncolytic specificity was associated with the adsorption spectrum of the virus ^2,3. The specificity was also expressed in vitro since virus transformed and oncogenic cells were susceptible to BEV-1, in contrast to cells of un-transformed lines and of primary cultures, which were resistant ⁴.