Musculoskeletal molecular imaging

a comprehensive overview

Marie K. Reumann, Mitchell C. Weiser, Philipp Mayer-Kuckuk

Research output: Contribution to journalReview article

15 Citations (Scopus)

Abstract

Molecular imaging permits non-invasive visualization and measurement of molecular and cell biology in living subjects, thereby complementing conventional anatomical imaging. Herein, we review the emerging application of molecular imaging for the study of musculoskeletal biology. Utilizing mainly bioluminescence and fluorescence techniques, molecular imaging has enabled in-vivo studies of (i) the activity of osteoblasts, osteoclasts, and hormones, (ii) the mechanisms of pathological cartilage and bone destruction, (iii) skeletal gene and cell therapy with and without biomaterial support, and (iv) the cellular processes in osteolysis and osteomyelitis. In these applications, musculoskeletal molecular imaging demonstrated feasibility for research in a myriad of musculoskeletal conditions ranging from bone fracture and arthritis to skeletal cancer. Importantly, these advances herald great potential for innovative clinical imaging in orthopedics, rheumatology, and oncology.

Original languageEnglish (US)
Pages (from-to)93-101
Number of pages9
JournalTrends in Biotechnology
Volume28
Issue number2
DOIs
StatePublished - Feb 1 2010

Fingerprint

Molecular imaging
Molecular Imaging
Bone
Cytology
Bioluminescence
Osteolysis
Molecular biology
Oncology
Osteoblasts
Bone Fractures
Hormones
Medical imaging
Orthopedics
Cartilage
Rheumatology
Biocompatible Materials
Osteoclasts
Osteomyelitis
Cell- and Tissue-Based Therapy
Biomaterials

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering

Cite this

Musculoskeletal molecular imaging : a comprehensive overview. / Reumann, Marie K.; Weiser, Mitchell C.; Mayer-Kuckuk, Philipp.

In: Trends in Biotechnology, Vol. 28, No. 2, 01.02.2010, p. 93-101.

Research output: Contribution to journalReview article

Reumann, Marie K. ; Weiser, Mitchell C. ; Mayer-Kuckuk, Philipp. / Musculoskeletal molecular imaging : a comprehensive overview. In: Trends in Biotechnology. 2010 ; Vol. 28, No. 2. pp. 93-101.
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