TY - JOUR
T1 - Musculoskeletal molecular imaging
T2 - a comprehensive overview
AU - Reumann, Marie K.
AU - Weiser, Mitchell C.
AU - Mayer-Kuckuk, Philipp
N1 - Funding Information:
We are indebted to Drs. P. Lassota (Boston, USA), C.-C. Glüer (Kiel, Germany), W. Semmler (Heidelberg, Germany), and R. Bhakta (New York, USA) for comments and corrections on the manuscript. Our work is supported by the National Institutes of Health (grant number AR055294 to PMK).
PY - 2010/2
Y1 - 2010/2
N2 - Molecular imaging permits non-invasive visualization and measurement of molecular and cell biology in living subjects, thereby complementing conventional anatomical imaging. Herein, we review the emerging application of molecular imaging for the study of musculoskeletal biology. Utilizing mainly bioluminescence and fluorescence techniques, molecular imaging has enabled in-vivo studies of (i) the activity of osteoblasts, osteoclasts, and hormones, (ii) the mechanisms of pathological cartilage and bone destruction, (iii) skeletal gene and cell therapy with and without biomaterial support, and (iv) the cellular processes in osteolysis and osteomyelitis. In these applications, musculoskeletal molecular imaging demonstrated feasibility for research in a myriad of musculoskeletal conditions ranging from bone fracture and arthritis to skeletal cancer. Importantly, these advances herald great potential for innovative clinical imaging in orthopedics, rheumatology, and oncology.
AB - Molecular imaging permits non-invasive visualization and measurement of molecular and cell biology in living subjects, thereby complementing conventional anatomical imaging. Herein, we review the emerging application of molecular imaging for the study of musculoskeletal biology. Utilizing mainly bioluminescence and fluorescence techniques, molecular imaging has enabled in-vivo studies of (i) the activity of osteoblasts, osteoclasts, and hormones, (ii) the mechanisms of pathological cartilage and bone destruction, (iii) skeletal gene and cell therapy with and without biomaterial support, and (iv) the cellular processes in osteolysis and osteomyelitis. In these applications, musculoskeletal molecular imaging demonstrated feasibility for research in a myriad of musculoskeletal conditions ranging from bone fracture and arthritis to skeletal cancer. Importantly, these advances herald great potential for innovative clinical imaging in orthopedics, rheumatology, and oncology.
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U2 - 10.1016/j.tibtech.2009.11.004
DO - 10.1016/j.tibtech.2009.11.004
M3 - Review article
C2 - 20045210
AN - SCOPUS:74049096174
SN - 0167-7799
VL - 28
SP - 93
EP - 101
JO - Trends in Biotechnology
JF - Trends in Biotechnology
IS - 2
ER -
