TY - JOUR
T1 - Murine leukemia virus infection in immunocompetent adult mice
AU - Tumas, Kathleen
AU - Overmoyer, Beth
AU - Clevenger, Charles V.
AU - Blank, Kenneth J.
AU - Prystowsky, Michael B.
PY - 1993/1
Y1 - 1993/1
N2 - The course of infection of a chronic murine leukemia virus (MuLV), E-55+, which induces thymic lymphoma/leukemia in 100% of mice infected as adults, was followed after inoculation of virus into adult mice which generate both cytotoxic T cell and neutralizing antibody responses (Blank 1976). DNA from the tissues of these infected mice was analyzed using a polymerase chain reaction assay to detect integrated provirus. Infection in adult immunocompetent BALB.K mice results in an acute phase characterized by a high number of cells containing provirus DNA followed by a period in which provirus DNA in most tissues reaches background levels until the development of thymic lymphoma/leukemia at 4-7 months. This pattern of infection is different from what has been observed in immunosuppressed mice in which levels of virus-infected cells remain high throughout the preleukemic and leukemic phases.
AB - The course of infection of a chronic murine leukemia virus (MuLV), E-55+, which induces thymic lymphoma/leukemia in 100% of mice infected as adults, was followed after inoculation of virus into adult mice which generate both cytotoxic T cell and neutralizing antibody responses (Blank 1976). DNA from the tissues of these infected mice was analyzed using a polymerase chain reaction assay to detect integrated provirus. Infection in adult immunocompetent BALB.K mice results in an acute phase characterized by a high number of cells containing provirus DNA followed by a period in which provirus DNA in most tissues reaches background levels until the development of thymic lymphoma/leukemia at 4-7 months. This pattern of infection is different from what has been observed in immunosuppressed mice in which levels of virus-infected cells remain high throughout the preleukemic and leukemic phases.
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U2 - 10.1006/viro.1993.1001
DO - 10.1006/viro.1993.1001
M3 - Article
C2 - 8390745
AN - SCOPUS:0027214727
SN - 0042-6822
VL - 192
SP - 1
EP - 10
JO - Virology
JF - Virology
IS - 1
ER -