Murine Leukemia Virus Infection in Immunocompetent Adult Mice

Kathleen Tumas, Beth Overmoyer, Charles V. Clevenger, Kenneth J. Blank, Michael B. Prystowsky

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The course of infection of a chronic murine leukemia virus (MuLV), E-55+, which induces thymic lymphoma/leukemia in 100% of mice infected as adults, was followed after inoculation of virus into adult mice which generate both cytotoxic T cell and neutralizing antibody responses (Blank 1976). DNA from the tissues of these infected mice was analyzed using a polymerase chain reaction assay to detect integrated provirus. Infection in adult immunocompetent BALB.K mice results in an acute phase characterized by a high number of cells containing provirus DNA followed by a period in which provirus DNA in most tissues reaches background levels until the development of thymic lymphoma/leukemia at 4-7 months. This pattern of infection is different from what has been observed in immunosuppressed mice in which levels of virus-infected cells remain high throughout the preleukemic and leukemic phases.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalVirology
Volume192
Issue number1
DOIs
StatePublished - Jan 1993
Externally publishedYes

Fingerprint

Murine Leukemia Viruses
Virus Diseases
Proviruses
Lymphoma
DNA
Leukemia
Infection
Viruses
Neutralizing Antibodies
Antibody Formation
Cell Count
T-Lymphocytes
Polymerase Chain Reaction

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

Cite this

Murine Leukemia Virus Infection in Immunocompetent Adult Mice. / Tumas, Kathleen; Overmoyer, Beth; Clevenger, Charles V.; Blank, Kenneth J.; Prystowsky, Michael B.

In: Virology, Vol. 192, No. 1, 01.1993, p. 1-10.

Research output: Contribution to journalArticle

Tumas, K, Overmoyer, B, Clevenger, CV, Blank, KJ & Prystowsky, MB 1993, 'Murine Leukemia Virus Infection in Immunocompetent Adult Mice', Virology, vol. 192, no. 1, pp. 1-10. https://doi.org/10.1006/viro.1993.1001
Tumas, Kathleen ; Overmoyer, Beth ; Clevenger, Charles V. ; Blank, Kenneth J. ; Prystowsky, Michael B. / Murine Leukemia Virus Infection in Immunocompetent Adult Mice. In: Virology. 1993 ; Vol. 192, No. 1. pp. 1-10.
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