Murine leukemia virus: detection of unintegrated double stranded DNA forms of the provirus

A. M. Gianni, David Smotkin, R. A. Weinberg

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Infection of JLS V9 (mouse bone marrow) cells with Moloney murine leukemia virus leads to appearance of virus specific DNA in the low molecular weight DNA fraction from infected cells. Most of this DNA is double stranded. Two discrete forms of double stranded DNA, both of molecular weight 6x106, have been characterized. One of these forms is closed circular, supercoiled DNA; the other form is a mixture of nicked circlar and linear DNA.

Original languageEnglish (US)
Pages (from-to)447-451
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume72
Issue number2
StatePublished - 1975
Externally publishedYes

Fingerprint

Proviruses
Murine Leukemia Viruses
DNA
Molecular Weight
Moloney murine leukemia virus
Superhelical DNA
Circular DNA
DNA Viruses
Bone Marrow Cells
Infection

ASJC Scopus subject areas

  • General
  • Genetics

Cite this

Murine leukemia virus : detection of unintegrated double stranded DNA forms of the provirus. / Gianni, A. M.; Smotkin, David; Weinberg, R. A.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 72, No. 2, 1975, p. 447-451.

Research output: Contribution to journalArticle

@article{160e90bc130b4a769daab48b9338d60d,
title = "Murine leukemia virus: detection of unintegrated double stranded DNA forms of the provirus",
abstract = "Infection of JLS V9 (mouse bone marrow) cells with Moloney murine leukemia virus leads to appearance of virus specific DNA in the low molecular weight DNA fraction from infected cells. Most of this DNA is double stranded. Two discrete forms of double stranded DNA, both of molecular weight 6x106, have been characterized. One of these forms is closed circular, supercoiled DNA; the other form is a mixture of nicked circlar and linear DNA.",
author = "Gianni, {A. M.} and David Smotkin and Weinberg, {R. A.}",
year = "1975",
language = "English (US)",
volume = "72",
pages = "447--451",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
number = "2",

}

TY - JOUR

T1 - Murine leukemia virus

T2 - detection of unintegrated double stranded DNA forms of the provirus

AU - Gianni, A. M.

AU - Smotkin, David

AU - Weinberg, R. A.

PY - 1975

Y1 - 1975

N2 - Infection of JLS V9 (mouse bone marrow) cells with Moloney murine leukemia virus leads to appearance of virus specific DNA in the low molecular weight DNA fraction from infected cells. Most of this DNA is double stranded. Two discrete forms of double stranded DNA, both of molecular weight 6x106, have been characterized. One of these forms is closed circular, supercoiled DNA; the other form is a mixture of nicked circlar and linear DNA.

AB - Infection of JLS V9 (mouse bone marrow) cells with Moloney murine leukemia virus leads to appearance of virus specific DNA in the low molecular weight DNA fraction from infected cells. Most of this DNA is double stranded. Two discrete forms of double stranded DNA, both of molecular weight 6x106, have been characterized. One of these forms is closed circular, supercoiled DNA; the other form is a mixture of nicked circlar and linear DNA.

UR - http://www.scopus.com/inward/record.url?scp=0016636263&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016636263&partnerID=8YFLogxK

M3 - Article

C2 - 1054828

AN - SCOPUS:0016636263

VL - 72

SP - 447

EP - 451

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 2

ER -