@inproceedings{41ef88a167a5435096328f35b391c3dc,
title = "Multiscale photoacoustic tomography of a genetically encoded near-infrared FRET biosensor",
abstract = "Photoacoustic tomography with genetically encoded near-infrared probes enables visualization of specific cell populations in vivo at high resolution in deep tissues. Here, we report a near-infrared Forster resonance energy transfer biosensor based on a pair of the near-infrared fluorescent proteins, miRFP670-iRFP720, which enables dynamic photoacoustic imaging of active biological processes. Specifically, we detected apoptosis in single cells at a resolution of 3m in a mouse ear and mouse brain tumors (>3 mm in depth) at a spatial resolution of 150m. These results open the way for high-resolution photoacoustic imaging of dynamic biological processes in deep tissues.",
keywords = "FRET, PAT, biosensor, photoacoustic microscopy",
author = "Lei Li and Lihong Wang and Verkhusha, {Vladislav V.} and Daria Shcherbakova",
note = "Publisher Copyright: {\textcopyright} 2022 SPIE.; Photons Plus Ultrasound: Imaging and Sensing 2022 ; Conference date: 20-02-2022 Through 24-02-2022",
year = "2022",
doi = "10.1117/12.2610587",
language = "English (US)",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Oraevsky, {Alexander A.} and Wang, {Lihong V.}",
booktitle = "Photons Plus Ultrasound",
}