Multiscale dynamics in nucleocytoplasmic transport

David Grünwald, Robert H. Singer

Research output: Contribution to journalReview article

20 Scopus citations

Abstract

The nuclear pore complex (NPC) has long been viewed as a point-like entry and exit channel between the nucleus and the cytoplasm. New data support a different view whereby the complex displays distinct spatial dynamics of variable duration ranging from milliseconds to events spanning the entire cell cycle. Discrete interaction sites outside the central channel become apparent, and transport regulation at these sites seems to be of greater importance than currently thought. Nuclear pore components are highly active outside the NPC or impact the fate of cargo transport away from the nuclear pore. The NPC is a highly dynamic, crowded environment - constantly loaded with cargo while providing selectivity based on unfolded proteins. Taken together, this comprises a new paradigm in how we view import/export dynamics and emphasizes the multiscale nature of NPC-mediated cellular transport.

Original languageEnglish (US)
Pages (from-to)100-106
Number of pages7
JournalCurrent Opinion in Cell Biology
Volume24
Issue number1
DOIs
StatePublished - Feb 1 2012

ASJC Scopus subject areas

  • Cell Biology

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