Multiplicative auditory spatial receptive fields created by a hierarchy of population codes

Brian J. Fischer, Charles H. Anderson, Jose L. Pena

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

A multiplicative combination of tuning to interaural time difference (ITD) and interaural level difference (ILD) contributes to the generation of spatially selective auditory neurons in the owl's midbrain. Previous analyses of multiplicative responses in the owl have not taken into consideration the frequency-dependence of ITD and ILD cues that occur under natural listening conditions. Here, we present a model for the responses of ITD- and ILD-sensitive neurons in the barn owl's inferior colliculus which satisfies constraints raised by experimental data on frequency convergence, multiplicative interaction of ITD and ILD, and response properties of afferent neurons. We propose that multiplication between ITD- and ILD-dependent signals occurs only within frequency channels and that frequency integration occurs using a linear-threshold mechanism. The model reproduces the experimentally observed nonlinear responses to ITD and ILD in the inferior colliculus, with greater accuracy than previous models. We show that linear-threshold frequency integration allows the system to represent multiple sound sources with natural sound localization cues, whereas multiplicative frequency integration does not. Nonlinear responses in the owl's inferior colliculus can thus be generated using a combination of cellular and network mechanisms, showing that multiple elements of previous theories can be combined in a single system.

Original languageEnglish (US)
Article numbere8015
JournalPLoS One
Volume4
Issue number11
DOIs
StatePublished - Nov 24 2009

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Strigiformes
Neurons
Inferior Colliculi
Acoustic waves
Population
Cues
Tuning
neurons
Sound Localization
Systems Integration
Tyto alba
Afferent Neurons
sensory neurons
Mesencephalon
brain

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Multiplicative auditory spatial receptive fields created by a hierarchy of population codes. / Fischer, Brian J.; Anderson, Charles H.; Pena, Jose L.

In: PLoS One, Vol. 4, No. 11, e8015, 24.11.2009.

Research output: Contribution to journalArticle

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