Multiple kinases and system robustness: A link between Cdc37 and genome integrity

Avrom J. Caplan, Avi Ma'Ayan, Ian M. Willis

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We identified 38 genes as having a genetic interaction with a mutant form of the kinase specific chaperone, Cdc37, using a genome-wide synthetic screening approach. The identified genes included a sub-network of highly interacting genes enriched for functions in genome integrity and comprising multiple components of several discrete molecular machines. A network analysis approach related these machines to a small group of cell cycle checkpoint kinases.

Original languageEnglish (US)
Pages (from-to)3145-3147
Number of pages3
JournalCell Cycle
Volume6
Issue number24
StatePublished - Dec 15 2007

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Phosphotransferases
Genes
Genome
Cell Cycle Checkpoints
Electric network analysis
Screening
Cells

Keywords

  • Cdc37
  • Cell cycle
  • Genome integrity
  • Molecular chaperone
  • Protein kinase
  • Synthetitc gene array

ASJC Scopus subject areas

  • Cell Biology
  • Biochemistry
  • Molecular Biology

Cite this

Multiple kinases and system robustness : A link between Cdc37 and genome integrity. / Caplan, Avrom J.; Ma'Ayan, Avi; Willis, Ian M.

In: Cell Cycle, Vol. 6, No. 24, 15.12.2007, p. 3145-3147.

Research output: Contribution to journalArticle

Caplan, Avrom J. ; Ma'Ayan, Avi ; Willis, Ian M. / Multiple kinases and system robustness : A link between Cdc37 and genome integrity. In: Cell Cycle. 2007 ; Vol. 6, No. 24. pp. 3145-3147.
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