Multiple kinases and system robustness: A link between Cdc37 and genome integrity

Avrom J. Caplan, Avi Ma'Ayan, Ian M. Willis

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

We identified 38 genes as having a genetic interaction with a mutant form of the kinase specific chaperone, Cdc37, using a genome-wide synthetic screening approach. The identified genes included a sub-network of highly interacting genes enriched for functions in genome integrity and comprising multiple components of several discrete molecular machines. A network analysis approach related these machines to a small group of cell cycle checkpoint kinases.

Original languageEnglish (US)
Pages (from-to)3145-3147
Number of pages3
JournalCell Cycle
Volume6
Issue number24
DOIs
StatePublished - Dec 15 2007

Keywords

  • Cdc37
  • Cell cycle
  • Genome integrity
  • Molecular chaperone
  • Protein kinase
  • Synthetitc gene array

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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