Multiple kinases and system robustness: A link between Cdc37 and genome integrity

Avrom J. Caplan; Avi Ma'Ayan; Ian M. Willis

doi:10.4161/cc.6.24.5147

Multiple kinases and system robustness: A link between Cdc37 and genome integrity

Avrom J. Caplan, Avi Ma'Ayan, Ian M. Willis

Biochemistry

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

We identified 38 genes as having a genetic interaction with a mutant form of the kinase specific chaperone, Cdc37, using a genome-wide synthetic screening approach. The identified genes included a sub-network of highly interacting genes enriched for functions in genome integrity and comprising multiple components of several discrete molecular machines. A network analysis approach related these machines to a small group of cell cycle checkpoint kinases.

Original language	English (US)
Pages (from-to)	3145-3147
Number of pages	3
Journal	Cell Cycle
Volume	6
Issue number	24
DOIs	https://doi.org/10.4161/cc.6.24.5147
State	Published - Dec 15 2007

Keywords

Cdc37
Cell cycle
Genome integrity
Molecular chaperone
Protein kinase
Synthetitc gene array

ASJC Scopus subject areas

Molecular Biology
Developmental Biology
Cell Biology

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10.4161/cc.6.24.5147

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abstract = "We identified 38 genes as having a genetic interaction with a mutant form of the kinase specific chaperone, Cdc37, using a genome-wide synthetic screening approach. The identified genes included a sub-network of highly interacting genes enriched for functions in genome integrity and comprising multiple components of several discrete molecular machines. A network analysis approach related these machines to a small group of cell cycle checkpoint kinases.",

keywords = "Cdc37, Cell cycle, Genome integrity, Molecular chaperone, Protein kinase, Synthetitc gene array",

author = "Caplan, {Avrom J.} and Avi Ma'Ayan and Willis, {Ian M.}",

note = "Funding Information: We are very grateful to Charlie Boone for providing the arrays of viable yeast gene-deletion strains and the SGA parent strain Y7092 for these studies. We also thank Huiming Ding for help with computed-based image analysis. This work was supported by National Institutes of Health grants GM70596 to A.J.C. and GM42728 to I.M.W. along with funds for the Singer RoToRHDA robot from the Department of Biochemistry, Albert Einstein College of Medicine and Dr. Steven Almo. A.M. thanks Ravi Iyengar for support from GM54508.",

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doi = "10.4161/cc.6.24.5147",

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Multiple kinases and system robustness: A link between Cdc37 and genome integrity

Abstract

Keywords

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