Multimodal MRI of Experimental Stroke

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

Stroke is the fourth leading cause of death and the leading cause of long-term disability in USA. Brain imaging data from experimental stroke models and stroke patients have shown that there is often a gradual progression of potentially reversible ischemic injury toward infarction. Reestablishing tissue perfusion and/or treating with neuroprotective drugs in a timely fashion are expected to salvage some ischemic tissues. Diffusion-weighted imaging based on magnetic resonance imaging (MRI) in which contrast is based on water motion can detect ischemic injury within minutes after onsets, whereas computed tomography and other imaging modalities fail to detect stroke injury for at least a few hours. Along with quantitative perfusion imaging, the perfusion-diffusion mismatch which approximates the ischemic penumbra could be imaged noninvasively. This review describes recent progresses in the development and application of multimodal MRI and image analysis techniques to study ischemic tissue at risk in experimental stroke in rats.

Original languageEnglish (US)
Pages (from-to)8-15
Number of pages8
JournalTranslational Stroke Research
Volume3
Issue number1
DOIs
StatePublished - Mar 2012
Externally publishedYes

Keywords

  • ADC
  • CBF
  • DWI
  • Experimental stroke model
  • fMRI
  • Hyperperfusion
  • Magnetic resonance imaging
  • MRI
  • Oxygen challenge
  • Perfusion-diffusion mismatch
  • Predictive mode
  • PWI
  • Rats
  • Rodents

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

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