TY - JOUR
T1 - Multicentric osteosarcoma, Rothmund-Thomson syndrome, and secondary nasopharyngeal non-Hodgkin's lymphoma
T2 - A case report and review of the literature
AU - Spurney, Christopher
AU - Gorlick, Richard
AU - Meyers, Paul A.
AU - Healey, John H.
AU - Huvos, Andrew G.
PY - 1998/9
Y1 - 1998/9
N2 - Purpose: Rothmund-Thomson syndrome (RTS) is an autosomal recessive disease characterized by poikiloderma, photosensitivity, skeletal deformities, and other changes. It is also associated with an increased risk of malignancies, including osteosarcoma. Sixteen previous cases of RTS and osteosarcoma have been reported. Patient: A patient with RTS in whom multicentric osteosarcoma developed is described. After surgery and chemotherapy, a secondary malignant neoplasm (SMN) developed consistent with nasopharyngeal non-Hodgkin's lymphoma. Results: The patient was treated with anti-CD20 monoclonal antibody and is in complete remission. Conclusion: This is the first report of a patient with RTS treated for osteosarcoma in whom a SMN developed. Potential factors involved in this SMN include genetic predisposition and previous chemotherapy.
AB - Purpose: Rothmund-Thomson syndrome (RTS) is an autosomal recessive disease characterized by poikiloderma, photosensitivity, skeletal deformities, and other changes. It is also associated with an increased risk of malignancies, including osteosarcoma. Sixteen previous cases of RTS and osteosarcoma have been reported. Patient: A patient with RTS in whom multicentric osteosarcoma developed is described. After surgery and chemotherapy, a secondary malignant neoplasm (SMN) developed consistent with nasopharyngeal non-Hodgkin's lymphoma. Results: The patient was treated with anti-CD20 monoclonal antibody and is in complete remission. Conclusion: This is the first report of a patient with RTS treated for osteosarcoma in whom a SMN developed. Potential factors involved in this SMN include genetic predisposition and previous chemotherapy.
KW - Non- Hodgkin's lymphoma
KW - Osteosarcoma
KW - Rothmund-Thomson syndrome
KW - Secondary malignant neoplasm
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U2 - 10.1097/00043426-199809000-00018
DO - 10.1097/00043426-199809000-00018
M3 - Article
C2 - 9787328
AN - SCOPUS:0032468161
SN - 1077-4114
VL - 20
SP - 494
EP - 497
JO - Journal of Pediatric Hematology/Oncology
JF - Journal of Pediatric Hematology/Oncology
IS - 5
ER -