Multicentric osteosarcoma, Rothmund-Thomson syndrome, and secondary nasopharyngeal non-Hodgkin's lymphoma

A case report and review of the literature

Christopher Spurney, Richard Gorlick, Paul A. Meyers, John H. Healey, Andrew G. Huvos

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Purpose: Rothmund-Thomson syndrome (RTS) is an autosomal recessive disease characterized by poikiloderma, photosensitivity, skeletal deformities, and other changes. It is also associated with an increased risk of malignancies, including osteosarcoma. Sixteen previous cases of RTS and osteosarcoma have been reported. Patient: A patient with RTS in whom multicentric osteosarcoma developed is described. After surgery and chemotherapy, a secondary malignant neoplasm (SMN) developed consistent with nasopharyngeal non-Hodgkin's lymphoma. Results: The patient was treated with anti-CD20 monoclonal antibody and is in complete remission. Conclusion: This is the first report of a patient with RTS treated for osteosarcoma in whom a SMN developed. Potential factors involved in this SMN include genetic predisposition and previous chemotherapy.

Original languageEnglish (US)
Pages (from-to)494-497
Number of pages4
JournalJournal of Pediatric Hematology/Oncology
Volume20
Issue number5
DOIs
StatePublished - Sep 1998
Externally publishedYes

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Rothmund-Thomson Syndrome
Osteosarcoma
Non-Hodgkin's Lymphoma
Neoplasms
Drug Therapy
Genetic Predisposition to Disease
Monoclonal Antibodies

Keywords

  • Non- Hodgkin's lymphoma
  • Osteosarcoma
  • Rothmund-Thomson syndrome
  • Secondary malignant neoplasm

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Hematology

Cite this

Multicentric osteosarcoma, Rothmund-Thomson syndrome, and secondary nasopharyngeal non-Hodgkin's lymphoma : A case report and review of the literature. / Spurney, Christopher; Gorlick, Richard; Meyers, Paul A.; Healey, John H.; Huvos, Andrew G.

In: Journal of Pediatric Hematology/Oncology, Vol. 20, No. 5, 09.1998, p. 494-497.

Research output: Contribution to journalArticle

Spurney, Christopher ; Gorlick, Richard ; Meyers, Paul A. ; Healey, John H. ; Huvos, Andrew G. / Multicentric osteosarcoma, Rothmund-Thomson syndrome, and secondary nasopharyngeal non-Hodgkin's lymphoma : A case report and review of the literature. In: Journal of Pediatric Hematology/Oncology. 1998 ; Vol. 20, No. 5. pp. 494-497.
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