Multi-tensor investigation of orbitofrontal cortex tracts affected in subcaudate tractotomy

Jimmy C. Yang, George Papadimitriou, Ryan Eckbo, Edward H. Yeterian, Lichen Liang, Darin D. Dougherty, Sylvain Bouix, Yogesh Rathi, Martha Shenton, Marek Kubicki, Emad N. Eskandar, Nikos Makris

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Subcaudate tractotomy (SCT) is a neurosurgical lesioning procedure that can reduce symptoms in medically intractable obsessive compulsive disorder (OCD). Due to the putative importance of the orbitofrontal cortex (OFC) in symptomatology, fibers that connect the OFC, SCT lesion, and either the thalamus or brainstem were investigated with two-tensor tractography using an unscented Kalman filter approach. From this dataset, fibers were warped to Montreal Neurological Institute space, and probability maps with center-of-mass analysis were subsequently generated. In comparing fibers from the same OFC region, including medial OFC (mOFC), central OFC (cOFC), and lateral OFC (lOFC), the area of divergence for fibers connected with the thalamus versus the brainstem is posterior to the anterior commissure. At the anterior commissure, fibers connected with the thalamus run dorsal to those connected with the brainstem. As OFC fibers travel through the ventral aspect of the internal capsule, lOFC fibers are dorsal to cOFC and mOFC fibers. Using neuroanatomical comparison, tracts coursing between the OFC and thalamus are likely part of the anterior thalamic radiations, while those between the OFC and brainstem likely belong to the medial forebrain bundle. These data support the involvement of the OFC in OCD and may be relevant to creating differential lesional procedures of specific tracts or to developing deep brain stimulation programming paradigms.

Original languageEnglish (US)
Pages (from-to)342-352
Number of pages11
JournalBrain Imaging and Behavior
Volume9
Issue number2
DOIs
StatePublished - Jun 27 2015
Externally publishedYes

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Prefrontal Cortex
Thalamus
Brain Stem
Obsessive-Compulsive Disorder
Medial Forebrain Bundle
Neurosurgical Procedures
Internal Capsule
Deep Brain Stimulation
Radiation

Keywords

  • Deep brain stimulation
  • Diffusion tensor imaging
  • Diffusion tractography
  • Obsessive-compulsive disorder
  • Psychosurgery

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Cognitive Neuroscience
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health
  • Behavioral Neuroscience

Cite this

Yang, J. C., Papadimitriou, G., Eckbo, R., Yeterian, E. H., Liang, L., Dougherty, D. D., ... Makris, N. (2015). Multi-tensor investigation of orbitofrontal cortex tracts affected in subcaudate tractotomy. Brain Imaging and Behavior, 9(2), 342-352. https://doi.org/10.1007/s11682-014-9314-z

Multi-tensor investigation of orbitofrontal cortex tracts affected in subcaudate tractotomy. / Yang, Jimmy C.; Papadimitriou, George; Eckbo, Ryan; Yeterian, Edward H.; Liang, Lichen; Dougherty, Darin D.; Bouix, Sylvain; Rathi, Yogesh; Shenton, Martha; Kubicki, Marek; Eskandar, Emad N.; Makris, Nikos.

In: Brain Imaging and Behavior, Vol. 9, No. 2, 27.06.2015, p. 342-352.

Research output: Contribution to journalArticle

Yang, JC, Papadimitriou, G, Eckbo, R, Yeterian, EH, Liang, L, Dougherty, DD, Bouix, S, Rathi, Y, Shenton, M, Kubicki, M, Eskandar, EN & Makris, N 2015, 'Multi-tensor investigation of orbitofrontal cortex tracts affected in subcaudate tractotomy', Brain Imaging and Behavior, vol. 9, no. 2, pp. 342-352. https://doi.org/10.1007/s11682-014-9314-z
Yang JC, Papadimitriou G, Eckbo R, Yeterian EH, Liang L, Dougherty DD et al. Multi-tensor investigation of orbitofrontal cortex tracts affected in subcaudate tractotomy. Brain Imaging and Behavior. 2015 Jun 27;9(2):342-352. https://doi.org/10.1007/s11682-014-9314-z
Yang, Jimmy C. ; Papadimitriou, George ; Eckbo, Ryan ; Yeterian, Edward H. ; Liang, Lichen ; Dougherty, Darin D. ; Bouix, Sylvain ; Rathi, Yogesh ; Shenton, Martha ; Kubicki, Marek ; Eskandar, Emad N. ; Makris, Nikos. / Multi-tensor investigation of orbitofrontal cortex tracts affected in subcaudate tractotomy. In: Brain Imaging and Behavior. 2015 ; Vol. 9, No. 2. pp. 342-352.
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