@article{27564ec821f24563b5b79e389072b9a7,
title = "Multi-region hemispheric specialization differentiates human from nonhuman primate brain function",
abstract = "The human behavioral repertoire greatly exceeds that of nonhuman primates. Anatomical specializations of the human brain include an enlarged neocortex and prefrontal cortex (Semendeferi et al. in Am J Phys Anthropol 114:224–241, 2001), but regional enlargements alone cannot account for these vast functional differences. Hemispheric specialization has long believed to be a major contributing factor to such distinctive human characteristics as motor dominance, attentional control and language. Yet structural cerebral asymmetries, documented in both humans and some nonhuman primate species, are relatively minor compared to behavioral lateralization. Identifying the mechanisms that underlie these functional differences remains a goal of considerable interest. Here, we investigate the intrinsic connectivity networks in four primate species (humans, chimpanzees, baboons, and capuchin monkeys) using resting-state fMRI to evaluate the intra- and inter- hemispheric coherences of spontaneous BOLD fluctuation. All three nonhuman primate species displayed lateralized functional networks that were strikingly similar to those observed in humans. However, only humans had multi-region lateralized networks, which provide fronto-parietal connectivity. Our results indicate that this pattern of within-hemisphere connectivity distinguishes humans from nonhuman primates.",
keywords = "Brain connectivity, Brain evolution, Functional connectivity, Primates, Resting-state networks, fMRI",
author = "Wey, {Hsiao Ying} and Phillips, {Kimberley A.} and McKay, {D. Reese} and Laird, {Angela R.} and Peter Kochunov and Davis, {M. Duff} and Glahn, {David C.} and Duong, {Timothy Q.} and Fox, {Peter T.}",
note = "Funding Information: This work was supported by the American Heart Association Established Investigator Award (0940104 N to T.Q.D.), National Institute of Health (NINDS R15 NS070717-01 to K.A.P.; NIA R01 AG29412-5 to M.D.D.; NINDS R01 NS45879 to T.Q.D.) and Clinical Translational Science Award?s imaging supplement (parent grant UL1RR025767) to K.A.P. and T.Q.D., and H.Y.W. H.Y.W. was supported by a Predoctoral Fellowship (11PRE5670005) from the American Heart Association and by a Translational Science Training Grant from the Institute for Integration of Medicine and Science, University of Texas Health Science Center. This project was also supported by the National Center for Research Resources (P51RR13986) and is currently supported by the Office of Research Infrastructure Programs/OD (P51OD011133) to M.D.D. We thank Nicholas Holder for technical assistance, and Drs. Kathy Brasky and Mel de la Garza for essential veterinary support. Funding Information: Acknowledgments This work was supported by the American Heart Association Established Investigator Award (0940104 N to T.Q.D.), National Institute of Health (NINDS R15 NS070717-01 to K.A.P.; NIA R01 AG29412-5 to M.D.D.; NINDS R01 NS45879 to T.Q.D.) and Clinical Translational Science Award{\textquoteright}s imaging supplement (parent grant UL1RR025767) to K.A.P. and T.Q.D., and H.Y.W. H.Y.W. was supported by a Predoctoral Fellowship (11PRE5670005) from the American Heart Association and by a Translational Science Training Grant from the Institute for Integration of Medicine and Science, University of Texas Health Science Center. This project was also supported by the National Center for Research Resources (P51RR13986) and is currently supported by the Office of Research Infrastructure Programs/OD (P51OD011133) to M.D.D. We thank Nicholas Holder for technical assistance, and Drs. Kathy Brasky and Mel de la Garza for essential veterinary support. Publisher Copyright: {\textcopyright} 2013, The Author(s).",
year = "2014",
month = nov,
day = "1",
doi = "10.1007/s00429-013-0620-9",
language = "English (US)",
volume = "219",
pages = "2187--2194",
journal = "Brain Structure and Function",
issn = "1863-2653",
number = "6",
}