mRNA on the move: The road to its biological destiny

Carolina Eliscovich, Adina R. Buxbaum, Zachary B. Katz, Robert H. Singer

Research output: Contribution to journalShort survey

42 Scopus citations

Abstract

Cells have evolved to regulate the asymmetric distribution of specific mRNA targets to institute spatial and temporal control over gene expression. Over the last few decades, evidence has mounted as to the importance of localization elements in the mRNA sequence and their respective RNA-binding proteins. Live imaging methodologies have shown mechanistic details of this phenomenon. In this minireview, we focus on the advanced biochemical and cell imaging techniques used to tweeze out the finer aspects of mechanisms of mRNA movement.

Original languageEnglish (US)
Pages (from-to)20361-20368
Number of pages8
JournalJournal of Biological Chemistry
Volume288
Issue number28
DOIs
StatePublished - Jul 12 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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