MRI perfusion in determining pseudoprogression in patients with glioblastoma

Robert J. Young, Ajay Gupta, Akash D. Shah, Jerome J. Graber, Timothy A. Chan, Zhigang Zhang, Weiji Shi, Kathryn Beal, Antonio M. Omuro

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

We examine the role of dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI) perfusion in differentiating pseudoprogression from progression in 20 consecutive patients with treated glioblastoma. MRI perfusion was performed, and relative cerebral blood volume (rCBV), relative peak height (rPH), and percent signal recovery (PSR) were measured. Pseudoprogression demonstrated lower median rCBV (P=009) and rPH (P<.001), and higher PSR (P=039) than progression. DSC MRI perfusion successfully identified pseudoprogression in patients who did not require a change in treatment despite radiographic worsening following chemoradiotherapy.

Original languageEnglish (US)
Pages (from-to)41-49
Number of pages9
JournalClinical Imaging
Volume37
Issue number1
DOIs
StatePublished - Jan 2013
Externally publishedYes

Fingerprint

Magnetic Resonance Angiography
Glioblastoma
Chemoradiotherapy
Cerebral Blood Volume
Therapeutics

Keywords

  • Glioblastoma
  • MRI perfusion
  • Progression
  • Pseudoprogression

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Young, R. J., Gupta, A., Shah, A. D., Graber, J. J., Chan, T. A., Zhang, Z., ... Omuro, A. M. (2013). MRI perfusion in determining pseudoprogression in patients with glioblastoma. Clinical Imaging, 37(1), 41-49. https://doi.org/10.1016/j.clinimag.2012.02.016

MRI perfusion in determining pseudoprogression in patients with glioblastoma. / Young, Robert J.; Gupta, Ajay; Shah, Akash D.; Graber, Jerome J.; Chan, Timothy A.; Zhang, Zhigang; Shi, Weiji; Beal, Kathryn; Omuro, Antonio M.

In: Clinical Imaging, Vol. 37, No. 1, 01.2013, p. 41-49.

Research output: Contribution to journalArticle

Young, RJ, Gupta, A, Shah, AD, Graber, JJ, Chan, TA, Zhang, Z, Shi, W, Beal, K & Omuro, AM 2013, 'MRI perfusion in determining pseudoprogression in patients with glioblastoma', Clinical Imaging, vol. 37, no. 1, pp. 41-49. https://doi.org/10.1016/j.clinimag.2012.02.016
Young, Robert J. ; Gupta, Ajay ; Shah, Akash D. ; Graber, Jerome J. ; Chan, Timothy A. ; Zhang, Zhigang ; Shi, Weiji ; Beal, Kathryn ; Omuro, Antonio M. / MRI perfusion in determining pseudoprogression in patients with glioblastoma. In: Clinical Imaging. 2013 ; Vol. 37, No. 1. pp. 41-49.
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