MRI of muscular fat

Fritz Schick, Jürgen Machann, Klaus Brechtel, Andrea Strempfer, Bernhard Klumpp, Daniel T. Stein, Stephan Jacob

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

An MRI technique with high selectivity and sensitivity to the signal components in the chemical shift range of methylene and methyl protons of fatty acids has been developed for noninvasive assessment of muscular fat in vivo. A spoiled gradient-echo sequence with spatial-spectral excitation by six equidistant pulses with 2°-(-9°)-17°-(-17°)-9°-(-2°) and a multi-echo train (TE = 16, 36, 56, 76, 96, and 116 ms) allowed a series of images to be recorded with a receiver bandwidth of 78 Hz per pixel. Sls from phantoms with lipid contents between 0.1% and 100% were compared to those from pure water. Thirty healthy volunteers underwent fat-selective imaging of their lower leg, and parallel localized proton spectroscopy of the tibialis anterior and the soleus muscle by a single-voxel stimulated echo acquisition mode (STEAM) technique (TR = 2 s, TE = 10 ms, TM = 15 ms). Results show a high correlation (r = 0.91) between fat imaging and the spectroscopic approach in the soleus muscle, considering the percentage total fat content of musculature. The correlation coefficient was clearly lower (r = 0.55) in the tibialis anterior muscle due to signal contaminations from adjacent subcutaneous fat in the images, inhomogeneous fat distribution, and generally lower lipid content in this muscle. Applications of the new imaging technique showed marked intra- and interindividual variability in the spatial distribution of lipids in the musculature of the lower leg. No significant correlation of the muscular fat with the thickness of the subcutaneous fat layer was found. In addition, the body mass index does not appear to determine muscular fat content, except in very obese cases.

Original languageEnglish (US)
Pages (from-to)720-727
Number of pages8
JournalMagnetic Resonance in Medicine
Volume47
Issue number4
DOIs
StatePublished - 2002

Fingerprint

Fats
Subcutaneous Fat
Lipids
Protons
Leg
Skeletal Muscle
Muscles
Spectrum Analysis
Healthy Volunteers
Body Mass Index
Fatty Acids
Water

Keywords

  • MRI
  • MRS
  • Muscular lipids
  • Skeletal muscle
  • Spatial-spectral excitation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Schick, F., Machann, J., Brechtel, K., Strempfer, A., Klumpp, B., Stein, D. T., & Jacob, S. (2002). MRI of muscular fat. Magnetic Resonance in Medicine, 47(4), 720-727. https://doi.org/10.1002/mrm.10107

MRI of muscular fat. / Schick, Fritz; Machann, Jürgen; Brechtel, Klaus; Strempfer, Andrea; Klumpp, Bernhard; Stein, Daniel T.; Jacob, Stephan.

In: Magnetic Resonance in Medicine, Vol. 47, No. 4, 2002, p. 720-727.

Research output: Contribution to journalArticle

Schick, F, Machann, J, Brechtel, K, Strempfer, A, Klumpp, B, Stein, DT & Jacob, S 2002, 'MRI of muscular fat', Magnetic Resonance in Medicine, vol. 47, no. 4, pp. 720-727. https://doi.org/10.1002/mrm.10107
Schick F, Machann J, Brechtel K, Strempfer A, Klumpp B, Stein DT et al. MRI of muscular fat. Magnetic Resonance in Medicine. 2002;47(4):720-727. https://doi.org/10.1002/mrm.10107
Schick, Fritz ; Machann, Jürgen ; Brechtel, Klaus ; Strempfer, Andrea ; Klumpp, Bernhard ; Stein, Daniel T. ; Jacob, Stephan. / MRI of muscular fat. In: Magnetic Resonance in Medicine. 2002 ; Vol. 47, No. 4. pp. 720-727.
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