MRI of blood flow of the human retina

Qi Peng, Yi Zhang, Oscar San Emeterio Nateras, Matthias J P Van Osch, Timothy Q. Duong

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

This study reports a high-resolution MRI approach to image basal blood flow and hypercapnia-induced blood-flow changes in the unanesthetized human retina on a 3-T MRI scanner. Pseudocontinuous arterial spin labeling technique with static tissue suppression was implemented to minimize movement artifacts and improve blood-flow sensitivity. Turbo spin-echo acquisition was used to achieve high spatial resolution free of susceptibility artifacts. The size, shape, and position of a custom-made receive radiofrequency coil were optimized for sensitivity in the posterior retina. Synchronized eye blink and respiration to the end of each data readout minimized eye movement and physiological fluctuation. Robust high-contrast blood-flow MRI of the unanesthetized human retina was obtained at 500 × 800 μm2 in-plane resolution. Blood flow in the posterior retina was 93 ± 31 mL/(100 mL min) (mean ± standard deviation, N = 5). Hypercapnic inhalation (5% CO2) increased blood flow by 12 ± 4% relative to air (P < 0.01, N = 5). This study demonstrates the feasibility of blood-flow MRI of the retina of unanesthetized human. Because blood flow is tightly coupled to metabolic function under normal conditions and it is often perturbed in diseases, this approach could provide unique insights into retinal physiology and serve as an objective imaging biomarker for disease staging and testing of novel therapeutic strategies. This approach could open up new avenue of retinal research. Magn Reson Med, 2011.

Original languageEnglish (US)
Pages (from-to)1768-1775
Number of pages8
JournalMagnetic Resonance in Medicine
Volume65
Issue number6
DOIs
StatePublished - Jun 2011
Externally publishedYes

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Retina
Artifacts
Hypercapnia
Feasibility Studies
Eye Movements
Inhalation
Respiration
Biomarkers
Air
Research

Keywords

  • ASL
  • choroids
  • high-resolution MRI
  • hypercapnia
  • retinal vessels

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Peng, Q., Zhang, Y., Nateras, O. S. E., Van Osch, M. J. P., & Duong, T. Q. (2011). MRI of blood flow of the human retina. Magnetic Resonance in Medicine, 65(6), 1768-1775. https://doi.org/10.1002/mrm.22763

MRI of blood flow of the human retina. / Peng, Qi; Zhang, Yi; Nateras, Oscar San Emeterio; Van Osch, Matthias J P; Duong, Timothy Q.

In: Magnetic Resonance in Medicine, Vol. 65, No. 6, 06.2011, p. 1768-1775.

Research output: Contribution to journalArticle

Peng, Q, Zhang, Y, Nateras, OSE, Van Osch, MJP & Duong, TQ 2011, 'MRI of blood flow of the human retina', Magnetic Resonance in Medicine, vol. 65, no. 6, pp. 1768-1775. https://doi.org/10.1002/mrm.22763
Peng Q, Zhang Y, Nateras OSE, Van Osch MJP, Duong TQ. MRI of blood flow of the human retina. Magnetic Resonance in Medicine. 2011 Jun;65(6):1768-1775. https://doi.org/10.1002/mrm.22763
Peng, Qi ; Zhang, Yi ; Nateras, Oscar San Emeterio ; Van Osch, Matthias J P ; Duong, Timothy Q. / MRI of blood flow of the human retina. In: Magnetic Resonance in Medicine. 2011 ; Vol. 65, No. 6. pp. 1768-1775.
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