MR imaging of caveolin gene-specific alterations in right ventricular wall thickness

Andrea Pereira De Souza, Alex W. Cohen, David S. Park, Scott E. Woodman, Baiyu Tang, David E. Gutstein, Stephen M. Factor, Herbert B. Tanowitz, Michael P. Lisanti, Linda A. Jelicks

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Caveolin-1 and caveolin-3 are expressed in the mammalian heart. Mice deficient in caveolin 1 or 3 exhibit cardiac abnormalities including left ventricular hypertrophy and reduced fractional shortening. Cardiac imaging technologies such as transthoracic echocardiography and cardiac-gated magnetic resonance imaging (MRI) are effective tools for the study of left ventricular morphology and function in mice; however, there has not been widespread use of these technologies in studies of right ventricular morphology. In particular, right ventricular wall thickness has been difficult to assess using cardiac imaging technologies. We report here the use of centerline analysis of cardiac-gated MR images to more accurately determine right ventricular wall thickness in the mouse heart. Right ventricular wall thickness was evaluated in Cav-1 null, Cav-3 null and Cav-1/3 null mice, as well as wild-type control mice. Using this technique, we find that caveolin null mice exhibit significant thickening of the right ventricular wall as compared with age-matched wild-type controls. Interestingly, right ventricular wall thickening is greatest in the Cav-1/3 null mice. Furthermore, significant right ventricular wall thickening is also seen in the Cav-1 null mice. Histological analyses revealed right ventricular hypertrophy consistent with the imaging results. These studies demonstrate the utility of MRI in determining right ventricular wall thickness and underscore the severity of the right ventricular hypertrophy in caveolin null mice.

Original languageEnglish (US)
Pages (from-to)61-68
Number of pages8
JournalMagnetic Resonance Imaging
Volume23
Issue number1
DOIs
StatePublished - Jan 2005

Fingerprint

Caveolins
genes
mice
Genes
Imaging techniques
Caveolin 3
Caveolin 1
Magnetic resonance
Right Ventricular Hypertrophy
Echocardiography
Technology
magnetic resonance
Magnetic Resonance Imaging
echocardiography
abnormalities
Left Ventricular Hypertrophy
Left Ventricular Function

Keywords

  • Caveolin
  • Centerline
  • Hypertrophy
  • Magnetic resonance imaging
  • Right ventricle

ASJC Scopus subject areas

  • Biophysics
  • Clinical Biochemistry
  • Structural Biology
  • Radiology Nuclear Medicine and imaging
  • Condensed Matter Physics

Cite this

De Souza, A. P., Cohen, A. W., Park, D. S., Woodman, S. E., Tang, B., Gutstein, D. E., ... Jelicks, L. A. (2005). MR imaging of caveolin gene-specific alterations in right ventricular wall thickness. Magnetic Resonance Imaging, 23(1), 61-68. https://doi.org/10.1016/j.mri.2004.11.011

MR imaging of caveolin gene-specific alterations in right ventricular wall thickness. / De Souza, Andrea Pereira; Cohen, Alex W.; Park, David S.; Woodman, Scott E.; Tang, Baiyu; Gutstein, David E.; Factor, Stephen M.; Tanowitz, Herbert B.; Lisanti, Michael P.; Jelicks, Linda A.

In: Magnetic Resonance Imaging, Vol. 23, No. 1, 01.2005, p. 61-68.

Research output: Contribution to journalArticle

De Souza, AP, Cohen, AW, Park, DS, Woodman, SE, Tang, B, Gutstein, DE, Factor, SM, Tanowitz, HB, Lisanti, MP & Jelicks, LA 2005, 'MR imaging of caveolin gene-specific alterations in right ventricular wall thickness', Magnetic Resonance Imaging, vol. 23, no. 1, pp. 61-68. https://doi.org/10.1016/j.mri.2004.11.011
De Souza, Andrea Pereira ; Cohen, Alex W. ; Park, David S. ; Woodman, Scott E. ; Tang, Baiyu ; Gutstein, David E. ; Factor, Stephen M. ; Tanowitz, Herbert B. ; Lisanti, Michael P. ; Jelicks, Linda A. / MR imaging of caveolin gene-specific alterations in right ventricular wall thickness. In: Magnetic Resonance Imaging. 2005 ; Vol. 23, No. 1. pp. 61-68.
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