MPHASYS

A mouse phenotype analysis system

R. Brent Calder, Rudolf B. Beems, Harry van Steeg, I. Saira Mian, Paul H M Lohman, Jan Vijg

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Systematic, high-throughput studies of mouse phenotypes have been hampered by the inability to analyze individual animal data from a multitude of sources in an integrated manner. Studies generally make comparisons at the level of genotype or treatment thereby excluding associations that may be subtle or involve compound phenotypes. Additionally, the lack of integrated, standardized ontologies and methodologies for data exchange has inhibited scientific collaboration and discovery. Results: Here we introduce a Mouse Phenotype Analysis System (MPHASYS), a platform for integrating data generated by studies of mouse models of human biology and disease such as aging and cancer. This computational platform is designed to provide a standardized methodology for working with animal data; a framework for data entry, analysis and sharing; and ontologies and methodologies for ensuring accurate data capture. We describe the tools that currently comprise MPHASYS, primarily ones related to mouse pathology, and outline its use in a study of individual animal-specific patterns of multiple pathology in mice harboring a specific germline mutation in the DNA repair and transcription-specific gene Xpd. Conclusion: MPHASYS is a system for analyzing multiple data types from individual animals. It provides a framework for developing data analysis applications, and tools for collecting and distributing high-quality data. The software is platform independent and freely available under an open-source license [1].

Original languageEnglish (US)
Article number183
JournalBMC Bioinformatics
Volume8
DOIs
StatePublished - Jun 6 2007
Externally publishedYes

Fingerprint

Systems Analysis
Phenotype
Mouse
Animals
Pathology
Ontology
Data acquisition
Electronic data interchange
Transcription
Methodology
DNA
Repair
Genes
Aging of materials
Throughput
Information Dissemination
Germ-Line Mutation
Data Quality
Data Exchange
Licensure

ASJC Scopus subject areas

  • Medicine(all)
  • Structural Biology
  • Applied Mathematics

Cite this

Calder, R. B., Beems, R. B., van Steeg, H., Mian, I. S., Lohman, P. H. M., & Vijg, J. (2007). MPHASYS: A mouse phenotype analysis system. BMC Bioinformatics, 8, [183]. https://doi.org/10.1186/1471-2105-8-183

MPHASYS : A mouse phenotype analysis system. / Calder, R. Brent; Beems, Rudolf B.; van Steeg, Harry; Mian, I. Saira; Lohman, Paul H M; Vijg, Jan.

In: BMC Bioinformatics, Vol. 8, 183, 06.06.2007.

Research output: Contribution to journalArticle

Calder, RB, Beems, RB, van Steeg, H, Mian, IS, Lohman, PHM & Vijg, J 2007, 'MPHASYS: A mouse phenotype analysis system', BMC Bioinformatics, vol. 8, 183. https://doi.org/10.1186/1471-2105-8-183
Calder RB, Beems RB, van Steeg H, Mian IS, Lohman PHM, Vijg J. MPHASYS: A mouse phenotype analysis system. BMC Bioinformatics. 2007 Jun 6;8. 183. https://doi.org/10.1186/1471-2105-8-183
Calder, R. Brent ; Beems, Rudolf B. ; van Steeg, Harry ; Mian, I. Saira ; Lohman, Paul H M ; Vijg, Jan. / MPHASYS : A mouse phenotype analysis system. In: BMC Bioinformatics. 2007 ; Vol. 8.
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