Abstract
The production of specific antibodies involves three diversification processes: V(D)J recombination, somatic hyper mutation (SHM), and class switch recombination (CSR). This chapter summarizes the many genetically manipulated mice that form the basis for the understanding of the biochemical basis of SHM and CSR. Although genetic defects in humans and studies done with cultured cells and cell-free biochemical systems are very important in advancing one's knowledge about the enzymes involved in these processes, it should be evident that mouse models lacking each of these enzymes were absolutely crucial, not only because they revealed the various pathways and activities in which they were involved but also because they provided an understanding of the relative importance of each of these pathways in vivo.
| Original language | English (US) |
|---|---|
| Title of host publication | The Mouse in Biomedical Research |
| Publisher | Elsevier Inc. |
| Pages | 155-168 |
| Number of pages | 14 |
| Volume | 4 |
| ISBN (Print) | 9780123694546 |
| DOIs | |
| State | Published - 2007 |
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- veterinary(all)
Cite this
Mouse Models revealed the Mechanisms for Somatic Hypermutation and Class Switch Recombination of Immunoglobulin Genes. / Iglesias-Ussel, Maria D.; Ziqiang, Li; Scharff, Matthew D.
The Mouse in Biomedical Research. Vol. 4 Elsevier Inc., 2007. p. 155-168.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Mouse Models revealed the Mechanisms for Somatic Hypermutation and Class Switch Recombination of Immunoglobulin Genes
AU - Iglesias-Ussel, Maria D.
AU - Ziqiang, Li
AU - Scharff, Matthew D.
PY - 2007
Y1 - 2007
N2 - The production of specific antibodies involves three diversification processes: V(D)J recombination, somatic hyper mutation (SHM), and class switch recombination (CSR). This chapter summarizes the many genetically manipulated mice that form the basis for the understanding of the biochemical basis of SHM and CSR. Although genetic defects in humans and studies done with cultured cells and cell-free biochemical systems are very important in advancing one's knowledge about the enzymes involved in these processes, it should be evident that mouse models lacking each of these enzymes were absolutely crucial, not only because they revealed the various pathways and activities in which they were involved but also because they provided an understanding of the relative importance of each of these pathways in vivo.
AB - The production of specific antibodies involves three diversification processes: V(D)J recombination, somatic hyper mutation (SHM), and class switch recombination (CSR). This chapter summarizes the many genetically manipulated mice that form the basis for the understanding of the biochemical basis of SHM and CSR. Although genetic defects in humans and studies done with cultured cells and cell-free biochemical systems are very important in advancing one's knowledge about the enzymes involved in these processes, it should be evident that mouse models lacking each of these enzymes were absolutely crucial, not only because they revealed the various pathways and activities in which they were involved but also because they provided an understanding of the relative importance of each of these pathways in vivo.
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UR - http://www.scopus.com/inward/citedby.url?scp=84884442218&partnerID=8YFLogxK
U2 - 10.1016/B978-012369454-6/50083-2
DO - 10.1016/B978-012369454-6/50083-2
M3 - Chapter
SN - 9780123694546
VL - 4
SP - 155
EP - 168
BT - The Mouse in Biomedical Research
PB - Elsevier Inc.
ER -