Mouse models for human familial adenomatous polyposis

Raju Kucherlapati, Diana P. Lin, Winfried Edelmann

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Colorectal cancer (CRC) is the second most frequent type of cancer in the Western hemisphere. In the United States alone, it is estimated that 150 000 new cases are detected every year and more than 65 000 patients die from complications associated with this cancer. Identification of genes implicated in the initiation and progression of colorectal cancer in humans has prompted the generation of mouse models for this cancer. We will provide a brief overview of these mouse models for CRC and what they have contributed to our understanding of the events involved in the initiation and progression of this cancer.

Original languageEnglish (US)
Pages (from-to)219-225
Number of pages7
JournalSeminars in Cancer Biology
Volume11
Issue number3
DOIs
StatePublished - Jan 1 2001

Keywords

  • Cancer
  • Colon
  • FAP
  • Mouse models

ASJC Scopus subject areas

  • Cancer Research

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