TY - JOUR
T1 - Motoric cognitive risk syndrome and risk of mortality in older adults
AU - Ayers, Emmeline
AU - Verghese, Joe
N1 - Funding Information:
The HRS is a nationally representative US cohort study of adults born between 1931 and 1941 [16,19–22] . HRS is sponsored by the National Institute on Aging (NIA; U01AG009740) and conducted by the University of Michigan. Further details of HRS recruitment and study design are published [16,19–22] . Half of the HRS cohort was randomly selected to receive physical performance tests in 2006 [20–22] . Participants aged >65 years who were ambulatory received timed walks. Of the 4686 in the total sample, 3977 were eligible for this analysis. Reasons for exclusion included self- or proxy-reported dementia diagnosis at baseline (n = 68), refusal (n = 118), safety concerns (n = 194), cognitive or physical limitations (n = 90), space constraints or equipment malfunction (n = 155), inaccurate walk time (n = 7), missing timed walk data (n = 40), or missing follow-up data (n = 37). Excluded participants were older (75.5 vs. 74.1 years, P < .001) and the majority were female (61.6 vs. 56.4%, P = .009).
Funding Information:
The HRS is sponsored by the National Institute on Aging (grant number U01AG009740 ) and is conducted by the University of Michigan. The NHATS is sponsored by the NIA (grant number U01AG032947 ) through a cooperative agreement with the Johns Hopkins Bloomberg School of Public Health. The SHARE data collection has been primarily funded by the European Commission through the 5th Framework Programme (project QLK6-CT-2001-00360 in the thematic programme Quality of Life), through the 6th Framework Programme (projects SHARE-I3, RII-CT-2006-062193, COMPARE, CIT5- CT-2005-028857, and SHARELIFE, CIT4-CT-2006-028812), and through the 7th Framework Programme (SHARE-PREP, N° 211909, SHARE-LEAP, N° 227822, and SHARE M4, N° 261982). Additional funding from the U.S. National Institute on Aging ( U01 AG09740-13S2 , P01 AG005842 , P01 AG08291 , P30 AG12815 , R21 AG025169 , Y1-AG-4553-01 , IAG BSR06-11 , and OGHA 04-064 ) and the German Ministry of Education and Research (Bundesministerium für Bildung und Forschung, BMBF) as well as from various national sources is gratefully acknowledged (see www.share-project.org for a full list of funding institutions). This article uses data from SHARE waves 1 and 2 release 2.6.0, as of November 29, 2013 (DOIs: 10.6103/SHARE.w1.260 and 10.6103/SHARE.w2.260 ) and SHARELIFE release 1.0.0, as of November 24, 2010 (DOI: 10.6103/SHARE.w3.100 ).
Publisher Copyright:
© 2016 Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
PY - 2016/5/1
Y1 - 2016/5/1
N2 - Introduction Cognitive impairment is associated with increased mortality. We examined the association between motoric cognitive risk (MCR) syndrome, a predementia syndrome characterized by slow gait and cognitive complaints, and survival. Methods A total of 11,867 nondemented participants aged >65 years from three established cohort studies in the United States and Europe were screened for MCR. Mortality risk of MCR was assessed with Cox and logistic regression models. Results At baseline, 836 (7.0%) participants had MCR. Over a median follow-up of 28 months, 1603 participants died (758 in first 2 years). MCR was associated with increased mortality overall (adjusted hazard ratio, 1.69; 95% confidence interval [CI], 1.46-1.96) and 2-year mortality (adjusted odds ratio, 1.89; 95% CI, 1.50-2.38). The association remained after accounting for established mortality risk factors as well as baseline gait speed and memory performance. Discussion MCR is associated with increased mortality. Older adults should be screened for MCR to identify at-risk individuals for dementia and death.
AB - Introduction Cognitive impairment is associated with increased mortality. We examined the association between motoric cognitive risk (MCR) syndrome, a predementia syndrome characterized by slow gait and cognitive complaints, and survival. Methods A total of 11,867 nondemented participants aged >65 years from three established cohort studies in the United States and Europe were screened for MCR. Mortality risk of MCR was assessed with Cox and logistic regression models. Results At baseline, 836 (7.0%) participants had MCR. Over a median follow-up of 28 months, 1603 participants died (758 in first 2 years). MCR was associated with increased mortality overall (adjusted hazard ratio, 1.69; 95% confidence interval [CI], 1.46-1.96) and 2-year mortality (adjusted odds ratio, 1.89; 95% CI, 1.50-2.38). The association remained after accounting for established mortality risk factors as well as baseline gait speed and memory performance. Discussion MCR is associated with increased mortality. Older adults should be screened for MCR to identify at-risk individuals for dementia and death.
KW - Cognitive impairment
KW - Dementia
KW - Gait speed
KW - Mortality
KW - Motoric cognitive risk syndrome
KW - Predementia syndromes
UR - http://www.scopus.com/inward/record.url?scp=84951849263&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84951849263&partnerID=8YFLogxK
U2 - 10.1016/j.jalz.2015.08.167
DO - 10.1016/j.jalz.2015.08.167
M3 - Article
C2 - 26545790
AN - SCOPUS:84951849263
SN - 1552-5260
VL - 12
SP - 556
EP - 564
JO - Alzheimer's and Dementia
JF - Alzheimer's and Dementia
IS - 5
ER -
