TY - JOUR
T1 - MOTHER-TO-INFANT TRANSMISSION OF HUMAN IMMUNODEFICIENCY VIRUS TYPE 1
T2 - ASSOCIATION WITH PREMATURITY OR LOW ANTI-gp120
AU - Goedert, James J.
AU - Drummond, James E.
AU - Minkoff, Howard L.
AU - Stevens, Roy
AU - Blattner, William A.
AU - Mendez, Hermann
AU - Robert-Guroff, Marjorie
AU - Holman, Susan
AU - Rubinstein, Arye
AU - Willoughby, Anne
AU - Landesman, Sheldon H.
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1989/12/9
Y1 - 1989/12/9
N2 - In a prospective study of pregnant women infected with human immunodeficiency virus type 1 (HIV-1) in Brooklyn, New York, USA, 16 (29%) of 55 evaluable infants were infected with HIV-1. 9 infants had paediatric acquired immunodeficiency syndrome, 6 had less severe clinical manifestations of HIV-1 infection, and 1 was symptom-free but was seropositive for HIV-1 beyond 15 months of age. The 10 infants born at 37 weeks of gestation or earlier were at higher risk of HIV-1 infection than infants born at 38 weeks of gestation or later (60% vs 22%) but the median age at appearance of disease was approximately 5 months in both groups. The HIV-1 transmission rate was not associated with predelivery levels of maternal T cells, anti-p24, or neutralising antibodies but it was higher, among full-term infants, for those with mothers in the lowest third of the distribution of anti-gp 120 levels (53%). On immunoblot, transmitting mothers lacked a gp120 band but not other bands. Protection was not associated with antibody to recombinant peptides from the hypervariable region of the major neutralising gp120 epitope, and the anti-gp120 endpoint dilution titre was similar in transmitting and non-transmitting mothers. Mothers of uninfected full-term infants appear to confer immunological protection against HIV-1 infection of their offspring by way of a high-affinity antibody to a gp120 epitope, whose specificity has importance for vaccine development and possibly perinatal immunotherapy.
AB - In a prospective study of pregnant women infected with human immunodeficiency virus type 1 (HIV-1) in Brooklyn, New York, USA, 16 (29%) of 55 evaluable infants were infected with HIV-1. 9 infants had paediatric acquired immunodeficiency syndrome, 6 had less severe clinical manifestations of HIV-1 infection, and 1 was symptom-free but was seropositive for HIV-1 beyond 15 months of age. The 10 infants born at 37 weeks of gestation or earlier were at higher risk of HIV-1 infection than infants born at 38 weeks of gestation or later (60% vs 22%) but the median age at appearance of disease was approximately 5 months in both groups. The HIV-1 transmission rate was not associated with predelivery levels of maternal T cells, anti-p24, or neutralising antibodies but it was higher, among full-term infants, for those with mothers in the lowest third of the distribution of anti-gp 120 levels (53%). On immunoblot, transmitting mothers lacked a gp120 band but not other bands. Protection was not associated with antibody to recombinant peptides from the hypervariable region of the major neutralising gp120 epitope, and the anti-gp120 endpoint dilution titre was similar in transmitting and non-transmitting mothers. Mothers of uninfected full-term infants appear to confer immunological protection against HIV-1 infection of their offspring by way of a high-affinity antibody to a gp120 epitope, whose specificity has importance for vaccine development and possibly perinatal immunotherapy.
UR - http://www.scopus.com/inward/record.url?scp=0024408384&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024408384&partnerID=8YFLogxK
U2 - 10.1016/S0140-6736(89)91965-X
DO - 10.1016/S0140-6736(89)91965-X
M3 - Article
C2 - 2574302
AN - SCOPUS:0024408384
SN - 0140-6736
VL - 334
SP - 1351
EP - 1354
JO - The Lancet
JF - The Lancet
IS - 8676
ER -