Motexafin-gadolinium and involved field radiation therapy for intrinsic pontine glioma of childhood: A children's oncology group phase 2 study

Kristin A. Bradley, Tianni Zhou, Rene Y. McNall-Knapp, Regina I. Jakacki, Adam S. Levy, Gilbert Vezina, Ian F. Pollack

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Purpose: To evaluate the effects on 1-year event-free survival (EFS) and overall survival (OS) of combining motexafin and gadolinium (MGd), a potent radiosensitizer, with daily fractionated radiation therapy in children with newly diagnosed intrinsic pontine gliomas. Methods and Materials: Patients with newly diagnosed intrinsic pontine glioma were treated with MGd daily for 5 consecutive days each week, for a total of 30 doses. Patients received a 5- to 10-min intravenous bolus of MGd, 4.4 mg/kg/day, given 2 to 5 h prior to standard dose irradiation. Radiation therapy was administered at a daily dose of 1.8 Gy for 30 treatments over 6 weeks. The total dose was 54 Gy. Results: Sixty eligible children received MGd daily, concurrent with 6 weeks of radiation therapy. The estimated 1-year EFS was 18% ± 5%, and the estimated 1-year OS was 53% ± 6.5%. The most common grade 3 to 4 toxicities were lymphopenia, transient elevation of liver transaminases, and hypertension. Conclusions: Compared to historical controls, the addition of MGd to a standard 6-week course of radiation did not improve the survival of pediatric patients with newly diagnosed intrinsic pontine gliomas.

Original languageEnglish (US)
Pages (from-to)e55-e60
JournalInternational Journal of Radiation Oncology Biology Physics
Volume85
Issue number1
DOIs
StatePublished - Jan 1 2013

ASJC Scopus subject areas

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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