Morphine-induced downregulation of mu-opioid receptors in neonatal rat brain.

A. Tempel, J. Habas, William Paredes, G. A. Barr

Research output: Contribution to journalArticle

Abstract

Chronic administration of morphine to pre- and postnatal rats produced a marked decrease in brain mu-opioid receptor density with-out change in receptor affinity. No significant changes in delta- or kappa-receptors were observed. This downregulation was accompanied by tolerance to the analgesic actions of morphine. In neonates exposed to morphine from postnatal day one, mu-receptor number was significantly depressed until postnatal day 8, then increased gradually to control levels by day 14 of treatment. Longer treatment produced no further change in opioid receptors. These data represent the first demonstration of in vivo downregulation of brain mu-opioid receptors following morphine administration and provide evidence for a unique plasticity of the immature opioid receptor system.

Original languageEnglish (US)
Pages (from-to)129-133
Number of pages5
JournalBrain Research
Volume469
Issue number1-2
StatePublished - Jun 1 1988

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mu Opioid Receptor
Morphine
Down-Regulation
Brain
Opioid Receptors
kappa Opioid Receptor
Analgesics

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Morphine-induced downregulation of mu-opioid receptors in neonatal rat brain. / Tempel, A.; Habas, J.; Paredes, William; Barr, G. A.

In: Brain Research, Vol. 469, No. 1-2, 01.06.1988, p. 129-133.

Research output: Contribution to journalArticle

Tempel, A, Habas, J, Paredes, W & Barr, GA 1988, 'Morphine-induced downregulation of mu-opioid receptors in neonatal rat brain.', Brain Research, vol. 469, no. 1-2, pp. 129-133.
Tempel, A. ; Habas, J. ; Paredes, William ; Barr, G. A. / Morphine-induced downregulation of mu-opioid receptors in neonatal rat brain. In: Brain Research. 1988 ; Vol. 469, No. 1-2. pp. 129-133.
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