Morphine-induced downregulation of μ-opioid receptors in neonatal rat brain

Ann Tempel, JoEllen Habas, William Paredes, Gordon A. Barr

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Chronic administration of morphine to pre- and postnatal rats produced a marked decrease in brain μ-opioid receptor density without a change in receptor affinity. No significant changes in δ- or κ-receptors were observed. This downregulation was accompanied by tolerance to the analgesic actions of morphine. In neonates exposed to morphine from postnatal day one, μ-receptor number was significantly depressed until postnatal day 8, then increased gradually to control levels by day 14 of treatment. Longer treatment produced no further change in opioid receptors. These data represent the first demonstration of in vivo downregulation of brain μ-opioid receptors following morphine administration and provide evidence for a unique plasticity of the immature opioid receptor system.

Original languageEnglish (US)
Pages (from-to)129-133
Number of pages5
JournalDevelopmental Brain Research
Volume41
Issue number1-2
DOIs
StatePublished - Jun 1 1988

Fingerprint

Opioid Receptors
Morphine
Down-Regulation
Brain
Analgesics

Keywords

  • Brain opioid receptor development
  • Brain μ-receptor
  • Chronic agonist
  • Downregulation
  • Morphine
  • Neonate
  • Tolerance

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience

Cite this

Morphine-induced downregulation of μ-opioid receptors in neonatal rat brain. / Tempel, Ann; Habas, JoEllen; Paredes, William; Barr, Gordon A.

In: Developmental Brain Research, Vol. 41, No. 1-2, 01.06.1988, p. 129-133.

Research output: Contribution to journalArticle

Tempel, Ann ; Habas, JoEllen ; Paredes, William ; Barr, Gordon A. / Morphine-induced downregulation of μ-opioid receptors in neonatal rat brain. In: Developmental Brain Research. 1988 ; Vol. 41, No. 1-2. pp. 129-133.
@article{91c2898c323e40b2bc34ec2942d6bda2,
title = "Morphine-induced downregulation of μ-opioid receptors in neonatal rat brain",
abstract = "Chronic administration of morphine to pre- and postnatal rats produced a marked decrease in brain μ-opioid receptor density without a change in receptor affinity. No significant changes in δ- or κ-receptors were observed. This downregulation was accompanied by tolerance to the analgesic actions of morphine. In neonates exposed to morphine from postnatal day one, μ-receptor number was significantly depressed until postnatal day 8, then increased gradually to control levels by day 14 of treatment. Longer treatment produced no further change in opioid receptors. These data represent the first demonstration of in vivo downregulation of brain μ-opioid receptors following morphine administration and provide evidence for a unique plasticity of the immature opioid receptor system.",
keywords = "Brain opioid receptor development, Brain μ-receptor, Chronic agonist, Downregulation, Morphine, Neonate, Tolerance",
author = "Ann Tempel and JoEllen Habas and William Paredes and Barr, {Gordon A.}",
year = "1988",
month = "6",
day = "1",
doi = "10.1016/0165-3806(88)90176-9",
language = "English (US)",
volume = "41",
pages = "129--133",
journal = "Developmental Brain Research",
issn = "0165-3806",
publisher = "Elsevier BV",
number = "1-2",

}

TY - JOUR

T1 - Morphine-induced downregulation of μ-opioid receptors in neonatal rat brain

AU - Tempel, Ann

AU - Habas, JoEllen

AU - Paredes, William

AU - Barr, Gordon A.

PY - 1988/6/1

Y1 - 1988/6/1

N2 - Chronic administration of morphine to pre- and postnatal rats produced a marked decrease in brain μ-opioid receptor density without a change in receptor affinity. No significant changes in δ- or κ-receptors were observed. This downregulation was accompanied by tolerance to the analgesic actions of morphine. In neonates exposed to morphine from postnatal day one, μ-receptor number was significantly depressed until postnatal day 8, then increased gradually to control levels by day 14 of treatment. Longer treatment produced no further change in opioid receptors. These data represent the first demonstration of in vivo downregulation of brain μ-opioid receptors following morphine administration and provide evidence for a unique plasticity of the immature opioid receptor system.

AB - Chronic administration of morphine to pre- and postnatal rats produced a marked decrease in brain μ-opioid receptor density without a change in receptor affinity. No significant changes in δ- or κ-receptors were observed. This downregulation was accompanied by tolerance to the analgesic actions of morphine. In neonates exposed to morphine from postnatal day one, μ-receptor number was significantly depressed until postnatal day 8, then increased gradually to control levels by day 14 of treatment. Longer treatment produced no further change in opioid receptors. These data represent the first demonstration of in vivo downregulation of brain μ-opioid receptors following morphine administration and provide evidence for a unique plasticity of the immature opioid receptor system.

KW - Brain opioid receptor development

KW - Brain μ-receptor

KW - Chronic agonist

KW - Downregulation

KW - Morphine

KW - Neonate

KW - Tolerance

UR - http://www.scopus.com/inward/record.url?scp=0023948749&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023948749&partnerID=8YFLogxK

U2 - 10.1016/0165-3806(88)90176-9

DO - 10.1016/0165-3806(88)90176-9

M3 - Article

C2 - 2841016

AN - SCOPUS:0023948749

VL - 41

SP - 129

EP - 133

JO - Developmental Brain Research

JF - Developmental Brain Research

SN - 0165-3806

IS - 1-2

ER -