Morphine-induced downregulation of μ-opioid receptors in neonatal rat brain

Ann Tempel; Jo Ellen Habas; William Paredes; Gordon A. Barr

doi:10.1016/0165-3806(88)90176-9

Morphine-induced downregulation of μ-opioid receptors in neonatal rat brain

Ann Tempel, Jo Ellen Habas, William Paredes, Gordon A. Barr

Medicine

Research output: Contribution to journal › Article › peer-review

93 Scopus citations

Abstract

Chronic administration of morphine to pre- and postnatal rats produced a marked decrease in brain μ-opioid receptor density without a change in receptor affinity. No significant changes in δ- or κ-receptors were observed. This downregulation was accompanied by tolerance to the analgesic actions of morphine. In neonates exposed to morphine from postnatal day one, μ-receptor number was significantly depressed until postnatal day 8, then increased gradually to control levels by day 14 of treatment. Longer treatment produced no further change in opioid receptors. These data represent the first demonstration of in vivo downregulation of brain μ-opioid receptors following morphine administration and provide evidence for a unique plasticity of the immature opioid receptor system.

Original language	English (US)
Pages (from-to)	129-133
Number of pages	5
Journal	Developmental Brain Research
Volume	41
Issue number	1-2
DOIs	https://doi.org/10.1016/0165-3806(88)90176-9
State	Published - Jun 1 1988

Keywords

Brain opioid receptor development
Brain μ-receptor
Chronic agonist
Downregulation
Morphine
Neonate
Tolerance

ASJC Scopus subject areas

Developmental Neuroscience
Developmental Biology

Access to Document

10.1016/0165-3806(88)90176-9

Cite this

@article{91c2898c323e40b2bc34ec2942d6bda2,

title = "Morphine-induced downregulation of μ-opioid receptors in neonatal rat brain",

abstract = "Chronic administration of morphine to pre- and postnatal rats produced a marked decrease in brain μ-opioid receptor density without a change in receptor affinity. No significant changes in δ- or κ-receptors were observed. This downregulation was accompanied by tolerance to the analgesic actions of morphine. In neonates exposed to morphine from postnatal day one, μ-receptor number was significantly depressed until postnatal day 8, then increased gradually to control levels by day 14 of treatment. Longer treatment produced no further change in opioid receptors. These data represent the first demonstration of in vivo downregulation of brain μ-opioid receptors following morphine administration and provide evidence for a unique plasticity of the immature opioid receptor system.",

keywords = "Brain opioid receptor development, Brain μ-receptor, Chronic agonist, Downregulation, Morphine, Neonate, Tolerance",

author = "Ann Tempel and Habas, {Jo Ellen} and William Paredes and Barr, {Gordon A.}",

year = "1988",

month = jun,

day = "1",

doi = "10.1016/0165-3806(88)90176-9",

language = "English (US)",

volume = "41",

pages = "129--133",

journal = "Developmental Brain Research",

issn = "0165-3806",

publisher = "Elsevier BV",

number = "1-2",

}

TY - JOUR

T1 - Morphine-induced downregulation of μ-opioid receptors in neonatal rat brain

AU - Tempel, Ann

AU - Habas, Jo Ellen

AU - Paredes, William

AU - Barr, Gordon A.

PY - 1988/6/1

Y1 - 1988/6/1

N2 - Chronic administration of morphine to pre- and postnatal rats produced a marked decrease in brain μ-opioid receptor density without a change in receptor affinity. No significant changes in δ- or κ-receptors were observed. This downregulation was accompanied by tolerance to the analgesic actions of morphine. In neonates exposed to morphine from postnatal day one, μ-receptor number was significantly depressed until postnatal day 8, then increased gradually to control levels by day 14 of treatment. Longer treatment produced no further change in opioid receptors. These data represent the first demonstration of in vivo downregulation of brain μ-opioid receptors following morphine administration and provide evidence for a unique plasticity of the immature opioid receptor system.

AB - Chronic administration of morphine to pre- and postnatal rats produced a marked decrease in brain μ-opioid receptor density without a change in receptor affinity. No significant changes in δ- or κ-receptors were observed. This downregulation was accompanied by tolerance to the analgesic actions of morphine. In neonates exposed to morphine from postnatal day one, μ-receptor number was significantly depressed until postnatal day 8, then increased gradually to control levels by day 14 of treatment. Longer treatment produced no further change in opioid receptors. These data represent the first demonstration of in vivo downregulation of brain μ-opioid receptors following morphine administration and provide evidence for a unique plasticity of the immature opioid receptor system.

KW - Brain opioid receptor development

KW - Brain μ-receptor

KW - Chronic agonist

KW - Downregulation

KW - Morphine

KW - Neonate

KW - Tolerance

UR - http://www.scopus.com/inward/record.url?scp=0023948749&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023948749&partnerID=8YFLogxK

U2 - 10.1016/0165-3806(88)90176-9

DO - 10.1016/0165-3806(88)90176-9

M3 - Article

C2 - 2841016

AN - SCOPUS:0023948749

SN - 0165-3806

VL - 41

SP - 129

EP - 133

JO - Developmental Brain Research

JF - Developmental Brain Research

IS - 1-2

ER -

Morphine-induced downregulation of μ-opioid receptors in neonatal rat brain

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this