Mood stabilizing effects of methadone in opioid use disorder patient

Jacob Gohari, Usman Riaz

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Lower doses of mood stabilizers may be necessary in patients receiving Methadone, especially when considering the metabolic syndrome and prolongation of QT interval which both Methadone and some psychoactive medications can cause. Research has shown that Methadone is a µ-opioid receptor agonist, as well as a serotonin and noradrenaline uptake inhibi-tor and NMDA receptor antagonist. Moreover, Methadone has the most evidence of efficacy in comorbid BD and opioid use disorder.We present here a case of a pregnant individual with a history of substance use disorder, BD-II and ADHD.

Original languageEnglish (US)
Pages (from-to)7-8
Number of pages2
JournalHeroin Addiction and Related Clinical Problems
Issue number1
StatePublished - Feb 2020


  • Bipolar disorder
  • Methadone
  • Opioid Use Disorder

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Psychiatry and Mental health


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