Mood, anxiety, and incomplete seizure control affect quality of life after epilepsy surgery

Hamada Hamid, Karen Blackmon, Xiangyu Cong, James Dziura, Lauren Y. Atlas, Barbara G. Vickrey, Anne T. Berg, Carl W. Bazil, John T. Langfitt, Thaddeus S. Walczak, Michael R. Sperling, Shlomo Shinnar, Orrin Devinsky

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Objective: We examined the complex relationship between depression, anxiety, and seizure control and quality of life (QOL) outcomes after epilepsy surgery. Methods: Seven epilepsy centers enrolled 373 patients and completed a comprehensive diagnostic workup and psychiatric and follow-up QOL evaluation. Subjects were evaluated before surgery and then at 3, 6, 12, 24, 48, and 60months after surgery. Standardized assessments included the Quality of Life in Epilepsy Inventory-89, Beck Depression Inventory (BDI), and Beck Anxiety Inventory (BAI). A mixed-model repeated-measures analysis was used to analyze associations of depression, anxiety, seizure outcome, and seizure history with overall QOL score and QOL subscores (cognitive distress, physical health, mental health, epilepsy-targeted) prospectively. Results: The groups with excellent and good seizure control showed a significant positive effect on the overall QOL compared to the groups with fair and poor seizure control. The BDI and BAI scores were both highly and negatively associated with overall QOL; increases in BDI and BAI scores were associated with decreased overall QOL score. Conclusions: Depression and anxiety are strongly and independently associated with worse QOL after epilepsy surgery. Interestingly, even partial seizure control, controlling for depression and anxiety levels, improved QOL. Management of mood and anxiety is a critical component to postsurgical care.

Original languageEnglish (US)
Pages (from-to)887-894
Number of pages8
JournalNeurology
Volume82
Issue number10
DOIs
StatePublished - Mar 11 2014

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Epilepsy
Seizures
Anxiety
Quality of Life
Depression
Equipment and Supplies
Mood
Surgery
Incomplete
Psychiatry
Mental Health
Health

ASJC Scopus subject areas

  • Clinical Neurology
  • Arts and Humanities (miscellaneous)

Cite this

Hamid, H., Blackmon, K., Cong, X., Dziura, J., Atlas, L. Y., Vickrey, B. G., ... Devinsky, O. (2014). Mood, anxiety, and incomplete seizure control affect quality of life after epilepsy surgery. Neurology, 82(10), 887-894. https://doi.org/10.1212/WNL0000000000000183

Mood, anxiety, and incomplete seizure control affect quality of life after epilepsy surgery. / Hamid, Hamada; Blackmon, Karen; Cong, Xiangyu; Dziura, James; Atlas, Lauren Y.; Vickrey, Barbara G.; Berg, Anne T.; Bazil, Carl W.; Langfitt, John T.; Walczak, Thaddeus S.; Sperling, Michael R.; Shinnar, Shlomo; Devinsky, Orrin.

In: Neurology, Vol. 82, No. 10, 11.03.2014, p. 887-894.

Research output: Contribution to journalArticle

Hamid, H, Blackmon, K, Cong, X, Dziura, J, Atlas, LY, Vickrey, BG, Berg, AT, Bazil, CW, Langfitt, JT, Walczak, TS, Sperling, MR, Shinnar, S & Devinsky, O 2014, 'Mood, anxiety, and incomplete seizure control affect quality of life after epilepsy surgery', Neurology, vol. 82, no. 10, pp. 887-894. https://doi.org/10.1212/WNL0000000000000183
Hamid H, Blackmon K, Cong X, Dziura J, Atlas LY, Vickrey BG et al. Mood, anxiety, and incomplete seizure control affect quality of life after epilepsy surgery. Neurology. 2014 Mar 11;82(10):887-894. https://doi.org/10.1212/WNL0000000000000183
Hamid, Hamada ; Blackmon, Karen ; Cong, Xiangyu ; Dziura, James ; Atlas, Lauren Y. ; Vickrey, Barbara G. ; Berg, Anne T. ; Bazil, Carl W. ; Langfitt, John T. ; Walczak, Thaddeus S. ; Sperling, Michael R. ; Shinnar, Shlomo ; Devinsky, Orrin. / Mood, anxiety, and incomplete seizure control affect quality of life after epilepsy surgery. In: Neurology. 2014 ; Vol. 82, No. 10. pp. 887-894.
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