Monocyte-mediated defense against bacteria, fungi, and parasites

Grégoire Lauvau, P'ng Loke, Tobias M. Hohl

Research output: Contribution to journalReview article

29 Scopus citations

Abstract

Circulating blood monocytes are a heterogeneous leukocyte population that contributes critical antimicrobial and regulatory functions during systemic and tissue-specific infections. These include patrolling vascular tissue for evidence of microbial invasion, infiltrating peripheral tissues and directly killing microbial invaders, conditioning the inflammatory milieu at sites of microbial tissue invasion, and orchestrating the activation of innate and adaptive immune effector cells. The central focus of this review is the in vivo mechanisms by which monocytes and their derivative cells promote microbial clearance and immune regulation. We include an overview of murine models to examine monocyte functions during microbial challenges and review our understanding of the functional roles of monocytes and their derivative cells in host defense against bacteria, fungi, and parasites.

Original languageEnglish (US)
Pages (from-to)397-409
Number of pages13
JournalSeminars in Immunology
Volume27
Issue number6
DOIs
Publication statusPublished - Dec 1 2015

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Keywords

  • Bacterium
  • Fungus
  • Inflammation
  • Innate immunity
  • Monocyte
  • Parasite

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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