@article{2d8e21f5634d4b4db8d1dd72380cd3e5,
title = "Monocyte-mediated defense against bacteria, fungi, and parasites",
abstract = "Circulating blood monocytes are a heterogeneous leukocyte population that contributes critical antimicrobial and regulatory functions during systemic and tissue-specific infections. These include patrolling vascular tissue for evidence of microbial invasion, infiltrating peripheral tissues and directly killing microbial invaders, conditioning the inflammatory milieu at sites of microbial tissue invasion, and orchestrating the activation of innate and adaptive immune effector cells. The central focus of this review is the in vivo mechanisms by which monocytes and their derivative cells promote microbial clearance and immune regulation. We include an overview of murine models to examine monocyte functions during microbial challenges and review our understanding of the functional roles of monocytes and their derivative cells in host defense against bacteria, fungi, and parasites.",
keywords = "Bacterium, Fungus, Inflammation, Innate immunity, Monocyte, Parasite",
author = "Gr{\'e}goire Lauvau and P'ng Loke and Hohl, {Tobias M.}",
note = "Funding Information: The authors receive support from NIH grants R01 093808, R21 105617 (to TMH), R01 103338, R21 095835 (to GL), AI 093811, AI 094166, DK 103788 (to PL), a Burroughs Wellcome Fund Investigator in the Pathogenesis of Infectious Diseases Award (to TMH), a Hirschl Caulier Award (to GL), the Broad Medical Research Program (to PL), and the Kevin and Marsha Keating Family Foundation (to PL). NIH Core GrantP30 CA008748 to MSKCC provided support for this manuscript. The authors are not aware of any biases that might be perceived as influencing the content of this review. The authors apologize to many contributors in the field whose work could not be cited due to space limitations Funding Information: The authors receive support from NIH grants R01 093808 , R21 105617 (to TMH), R01 103338 , R21 095835 (to GL), AI 093811 , AI 094166 , DK 103788 (to PL), a Burroughs Wellcome Fund Investigator in the Pathogenesis of Infectious Diseases Award (to TMH), a Hirschl Caulier Award (to GL), the Broad Medical Research Program (to PL), and the Kevin and Marsha Keating Family Foundation (to PL). NIH Core Grant P30 CA008748 to MSKCC provided support for this manuscript. The authors are not aware of any biases that might be perceived as influencing the content of this review. The authors apologize to many contributors in the field whose work could not be cited due to space limitations. Publisher Copyright: {\textcopyright} 2016 Elsevier Ltd.",
year = "2015",
month = dec,
day = "1",
doi = "10.1016/j.smim.2016.03.014",
language = "English (US)",
volume = "27",
pages = "397--409",
journal = "Seminars in Immunology",
issn = "1044-5323",
publisher = "Academic Press Inc.",
number = "6",
}