Monoclonal antibody to fungal glucosylceramide protects mice against lethal Cryptococcus neoformans infection

Marcio L. Rodrigues, Li Shi, Eliana Barreto-Bergter, Leonardo Nimrichter, Sandra E. Farias, Elaine G. Rodrigues, Luiz R. Travassos, Joshua D. Nosanchuk

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Glucosylceramides (GlcCer) are involved in the regulation of Cryptococcus neoformans virulence. In the present study, we demonstrate that passive immunization with a monoclonal antibody to GlcCer significantly reduces host inflammation and prolongs the survival of mice lethally infected with C. neoformans, revealing a potential therapeutic strategy to control cryptococcosis.

Original languageEnglish (US)
Pages (from-to)1372-1376
Number of pages5
JournalClinical and Vaccine Immunology
Volume14
Issue number10
DOIs
StatePublished - Oct 2007

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Glucosylceramides
Cryptococcus neoformans
Monoclonal Antibodies
Immunization
Cryptococcosis
Passive Immunization
Infection
Virulence
Inflammation
Therapeutics

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Immunology
  • Immunology and Allergy
  • Microbiology (medical)

Cite this

Monoclonal antibody to fungal glucosylceramide protects mice against lethal Cryptococcus neoformans infection. / Rodrigues, Marcio L.; Shi, Li; Barreto-Bergter, Eliana; Nimrichter, Leonardo; Farias, Sandra E.; Rodrigues, Elaine G.; Travassos, Luiz R.; Nosanchuk, Joshua D.

In: Clinical and Vaccine Immunology, Vol. 14, No. 10, 10.2007, p. 1372-1376.

Research output: Contribution to journalArticle

Rodrigues, ML, Shi, L, Barreto-Bergter, E, Nimrichter, L, Farias, SE, Rodrigues, EG, Travassos, LR & Nosanchuk, JD 2007, 'Monoclonal antibody to fungal glucosylceramide protects mice against lethal Cryptococcus neoformans infection', Clinical and Vaccine Immunology, vol. 14, no. 10, pp. 1372-1376. https://doi.org/10.1128/CVI.00202-07
Rodrigues, Marcio L. ; Shi, Li ; Barreto-Bergter, Eliana ; Nimrichter, Leonardo ; Farias, Sandra E. ; Rodrigues, Elaine G. ; Travassos, Luiz R. ; Nosanchuk, Joshua D. / Monoclonal antibody to fungal glucosylceramide protects mice against lethal Cryptococcus neoformans infection. In: Clinical and Vaccine Immunology. 2007 ; Vol. 14, No. 10. pp. 1372-1376.
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