TY - JOUR
T1 - Monoclonal antibody to fungal glucosylceramide protects mice against lethal Cryptococcus neoformans infection
AU - Rodrigues, Marcio L.
AU - Shi, Li
AU - Barreto-Bergter, Eliana
AU - Nimrichter, Leonardo
AU - Farias, Sandra E.
AU - Rodrigues, Elaine G.
AU - Travassos, Luiz R.
AU - Nosanchuk, Joshua D.
PY - 2007/10
Y1 - 2007/10
N2 - Glucosylceramides (GlcCer) are involved in the regulation of Cryptococcus neoformans virulence. In the present study, we demonstrate that passive immunization with a monoclonal antibody to GlcCer significantly reduces host inflammation and prolongs the survival of mice lethally infected with C. neoformans, revealing a potential therapeutic strategy to control cryptococcosis.
AB - Glucosylceramides (GlcCer) are involved in the regulation of Cryptococcus neoformans virulence. In the present study, we demonstrate that passive immunization with a monoclonal antibody to GlcCer significantly reduces host inflammation and prolongs the survival of mice lethally infected with C. neoformans, revealing a potential therapeutic strategy to control cryptococcosis.
UR - http://www.scopus.com/inward/record.url?scp=35549002249&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=35549002249&partnerID=8YFLogxK
U2 - 10.1128/CVI.00202-07
DO - 10.1128/CVI.00202-07
M3 - Article
C2 - 17715331
AN - SCOPUS:35549002249
SN - 1556-6811
VL - 14
SP - 1372
EP - 1376
JO - Clinical and Vaccine Immunology
JF - Clinical and Vaccine Immunology
IS - 10
ER -