Monoclonal antibodies to lipoarabinomannan/arabinomannan – characteristics and implications for tuberculosis research and diagnostics

Devin T. Corrigan, Elise Ishida, Delphi Chatterjee, Todd L. Lowary, Jacqueline M. Achkar

Research output: Contribution to journalReview articlepeer-review

Abstract

Antibodies to the mycobacterial surface lipoglycan lipoarabinomannan (LAM) and its related capsular polysaccharide arabinomannan (AM) are increasingly important for investigations focused on both understanding mechanisms of protection against Mycobacterium tuberculosis (Mtb) and developing next-generation point-of-care tuberculosis (TB) diagnostics. We provide here an overview of the growing pipeline of monoclonal antibodies (mAbs) to LAM/AM. Old and new methodologies for their generation are reviewed and we outline and discuss their glycan epitope specificity and other features with implications for the TB field.

Original languageEnglish (US)
JournalTrends in Microbiology
DOIs
StateAccepted/In press - 2022

Keywords

  • antigen–antibody interactions
  • biomarker
  • glycans
  • lipoglycans
  • mycobacteria
  • oligosaccharides
  • point-of-care tests

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases
  • Virology

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