TY - JOUR
T1 - Monoclonal Antibodies
T2 - A New Technology for Producing Serologic Reagents
AU - Diamond, Betty A.
AU - Yelton, Dale E.
AU - Scharff, Matthew D.
PY - 1981/5/28
Y1 - 1981/5/28
N2 - FOR many years antibodies have had a major role in the diagnosis of a wide variety of diseases. Radioimmunoassays and other immunologic assays are now used extensively in diagnostic laboratories to detect and quantitate drugs, bacterial and viral products, tumor antigens, and circulating immunoglobulins. However, immunologic assays have always been plagued by uncertainties that result from the unpredictability and heterogeneity of the immune response. Immunization is still more of an art than a science, and serologists have had to be satisfied with whatever quality and quantity of antibodies an immunized animal will provide. Even when apparently pure antigen is used.
AB - FOR many years antibodies have had a major role in the diagnosis of a wide variety of diseases. Radioimmunoassays and other immunologic assays are now used extensively in diagnostic laboratories to detect and quantitate drugs, bacterial and viral products, tumor antigens, and circulating immunoglobulins. However, immunologic assays have always been plagued by uncertainties that result from the unpredictability and heterogeneity of the immune response. Immunization is still more of an art than a science, and serologists have had to be satisfied with whatever quality and quantity of antibodies an immunized animal will provide. Even when apparently pure antigen is used.
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U2 - 10.1056/NEJM198105283042208
DO - 10.1056/NEJM198105283042208
M3 - Review article
C2 - 6783911
AN - SCOPUS:0019871057
SN - 0028-4793
VL - 304
SP - 1344
EP - 1349
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 22
ER -