Molecular pathophysiology and physical chemistry of cholesterol gallstones

Helen H. Wang, Piero Portincasa, David Q.H. Wang

Research output: Contribution to journalReview article

59 Citations (Scopus)

Abstract

Cholesterol gallstones are one of the most prevalent and most costly digestive diseases in the developed countries. Although precipitation of cholesterol from supersaturated bile is the first irreversible physical-chemical step in cholesterol gallstone formation, hepatic hypersecretion of biliary cholesterol is the primary defect in the formation of cholesterol gallstones. The other common abnormalities of the hepatobiliary system in gallstone patients include accelerated cholesterol nucleation/crystallization, gallbladder hypomotility, hypersecretion and accumulation of mucins, high efficiency of intestinal cholesterol absorption and slow intestinal motility. Family and twin studies in humans as well as gallstone prevalence investigations in different strains of inbred mice have clearly demonstrated that a complex genetic basis could determine individual predisposition to develop cholesterol gallstones in response to environmental factors such as high dietary cholesterol. In this review, we summarize progress in understanding the molecular pathophysiology of cholesterol gallstone formation with particular reference to most recent advances in the physical-chemistry of bile and the physiology of biliary lipid secretion.

Original languageEnglish (US)
Pages (from-to)401-423
Number of pages23
JournalFrontiers in Bioscience
Volume13
Issue number2
DOIs
StatePublished - May 5 2008
Externally publishedYes

Fingerprint

Physical Chemistry
Physical chemistry
Gallstones
Cholesterol
Bile
Dietary Cholesterol
Twin Studies
Inbred Strains Mice
Gastrointestinal Motility
Intestinal Absorption
Physiology
Mucins
Crystallization
Gallbladder
Developed Countries
Nucleation

Keywords

  • Bile flow
  • Bile salt
  • Biliary lipid secretion
  • Cholesterol
  • Crystallization
  • Lipid transporter
  • Liquid crystal
  • Micelle
  • Nucleation
  • Phase diagram
  • Phospholipid
  • Review
  • Vesicle

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Molecular pathophysiology and physical chemistry of cholesterol gallstones. / Wang, Helen H.; Portincasa, Piero; Wang, David Q.H.

In: Frontiers in Bioscience, Vol. 13, No. 2, 05.05.2008, p. 401-423.

Research output: Contribution to journalReview article

Wang, Helen H. ; Portincasa, Piero ; Wang, David Q.H. / Molecular pathophysiology and physical chemistry of cholesterol gallstones. In: Frontiers in Bioscience. 2008 ; Vol. 13, No. 2. pp. 401-423.
@article{8668394c815a4b54b88c4bc273c7295f,
title = "Molecular pathophysiology and physical chemistry of cholesterol gallstones",
abstract = "Cholesterol gallstones are one of the most prevalent and most costly digestive diseases in the developed countries. Although precipitation of cholesterol from supersaturated bile is the first irreversible physical-chemical step in cholesterol gallstone formation, hepatic hypersecretion of biliary cholesterol is the primary defect in the formation of cholesterol gallstones. The other common abnormalities of the hepatobiliary system in gallstone patients include accelerated cholesterol nucleation/crystallization, gallbladder hypomotility, hypersecretion and accumulation of mucins, high efficiency of intestinal cholesterol absorption and slow intestinal motility. Family and twin studies in humans as well as gallstone prevalence investigations in different strains of inbred mice have clearly demonstrated that a complex genetic basis could determine individual predisposition to develop cholesterol gallstones in response to environmental factors such as high dietary cholesterol. In this review, we summarize progress in understanding the molecular pathophysiology of cholesterol gallstone formation with particular reference to most recent advances in the physical-chemistry of bile and the physiology of biliary lipid secretion.",
keywords = "Bile flow, Bile salt, Biliary lipid secretion, Cholesterol, Crystallization, Lipid transporter, Liquid crystal, Micelle, Nucleation, Phase diagram, Phospholipid, Review, Vesicle",
author = "Wang, {Helen H.} and Piero Portincasa and Wang, {David Q.H.}",
year = "2008",
month = "5",
day = "5",
doi = "10.2741/2688",
language = "English (US)",
volume = "13",
pages = "401--423",
journal = "Frontiers in Bioscience - Landmark",
issn = "1093-9946",
publisher = "Frontiers in Bioscience",
number = "2",

}

TY - JOUR

T1 - Molecular pathophysiology and physical chemistry of cholesterol gallstones

AU - Wang, Helen H.

AU - Portincasa, Piero

AU - Wang, David Q.H.

PY - 2008/5/5

Y1 - 2008/5/5

N2 - Cholesterol gallstones are one of the most prevalent and most costly digestive diseases in the developed countries. Although precipitation of cholesterol from supersaturated bile is the first irreversible physical-chemical step in cholesterol gallstone formation, hepatic hypersecretion of biliary cholesterol is the primary defect in the formation of cholesterol gallstones. The other common abnormalities of the hepatobiliary system in gallstone patients include accelerated cholesterol nucleation/crystallization, gallbladder hypomotility, hypersecretion and accumulation of mucins, high efficiency of intestinal cholesterol absorption and slow intestinal motility. Family and twin studies in humans as well as gallstone prevalence investigations in different strains of inbred mice have clearly demonstrated that a complex genetic basis could determine individual predisposition to develop cholesterol gallstones in response to environmental factors such as high dietary cholesterol. In this review, we summarize progress in understanding the molecular pathophysiology of cholesterol gallstone formation with particular reference to most recent advances in the physical-chemistry of bile and the physiology of biliary lipid secretion.

AB - Cholesterol gallstones are one of the most prevalent and most costly digestive diseases in the developed countries. Although precipitation of cholesterol from supersaturated bile is the first irreversible physical-chemical step in cholesterol gallstone formation, hepatic hypersecretion of biliary cholesterol is the primary defect in the formation of cholesterol gallstones. The other common abnormalities of the hepatobiliary system in gallstone patients include accelerated cholesterol nucleation/crystallization, gallbladder hypomotility, hypersecretion and accumulation of mucins, high efficiency of intestinal cholesterol absorption and slow intestinal motility. Family and twin studies in humans as well as gallstone prevalence investigations in different strains of inbred mice have clearly demonstrated that a complex genetic basis could determine individual predisposition to develop cholesterol gallstones in response to environmental factors such as high dietary cholesterol. In this review, we summarize progress in understanding the molecular pathophysiology of cholesterol gallstone formation with particular reference to most recent advances in the physical-chemistry of bile and the physiology of biliary lipid secretion.

KW - Bile flow

KW - Bile salt

KW - Biliary lipid secretion

KW - Cholesterol

KW - Crystallization

KW - Lipid transporter

KW - Liquid crystal

KW - Micelle

KW - Nucleation

KW - Phase diagram

KW - Phospholipid

KW - Review

KW - Vesicle

UR - http://www.scopus.com/inward/record.url?scp=37349028141&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=37349028141&partnerID=8YFLogxK

U2 - 10.2741/2688

DO - 10.2741/2688

M3 - Review article

C2 - 17981556

AN - SCOPUS:37349028141

VL - 13

SP - 401

EP - 423

JO - Frontiers in Bioscience - Landmark

JF - Frontiers in Bioscience - Landmark

SN - 1093-9946

IS - 2

ER -