Molecular Optical Imaging of Therapeutic Targets of Cancer

Konstantin Sokolov, Dawn Nida, Michael Descour, Alicia Lacy, Matthew Levy, Brad Hall, Su Dharmawardhane, Andrew Ellington, Brian Korgel, Rebecca Richards-Kortum

Research output: Contribution to journalReview article

25 Scopus citations

Abstract

Recent progress in discerning the molecular events that accompany carcinogenesis has led to development of new cancer therapies directly targeted against the molecular changes of neoplasia. Molecular-targeted therapeutics have shown significant improvements in response rates and decreased toxicity as compared to conventional cytotoxic therapies which lack specificity for tumor cells. In order to fully explore the potential of molecular-targeted therapy, a new set of tools is required to dynamically and quantitatively image and monitor the heterogeneous molecular profiles of tumors in vivo. Currently, molecular markers can only be visualized in vitro using complex immunohistochemical staining protocols. In this chapter, we discuss emerging optical tools to image in vivo a molecular profile of risk-based hallmarks of cancer for selecting and monitoring therapy. We present the combination of optically active, targeted nanoparticles for molecular imaging with advances in minimally invasive optical imaging systems, which can be used to dynamically image both a molecular and phenotypic profile of risk and to monitor changes in this profile during therapy.

Original languageEnglish (US)
Pages (from-to)299-344
Number of pages46
JournalAdvances in Cancer Research
Volume96
DOIs
Publication statusPublished - Dec 8 2006

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Sokolov, K., Nida, D., Descour, M., Lacy, A., Levy, M., Hall, B., ... Richards-Kortum, R. (2006). Molecular Optical Imaging of Therapeutic Targets of Cancer. Advances in Cancer Research, 96, 299-344. https://doi.org/10.1016/S0065-230X(06)96011-4