Molecular mechanisms of aluminum neurotoxicity: Update on adverse effects and therapeutic strategies

Anatoly V. Skalny; Michael Aschner; Yueming Jiang; Yordanka G. Gluhcheva; Yousef Tizabi; Ryszard Lobinski; Alexey A. Tinkov

doi:10.1016/bs.ant.2020.12.001

Molecular mechanisms of aluminum neurotoxicity: Update on adverse effects and therapeutic strategies

Anatoly V. Skalny, Michael Aschner, Yueming Jiang, Yordanka G. Gluhcheva, Yousef Tizabi, Ryszard Lobinski, Alexey A. Tinkov

Molecular Pharmacology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

26 Scopus citations

Abstract

Recent studies have demonstrated that brain may be considered as the target for aluminium (Al) toxicity, resulting in development of neurodegenerative and neurodevelopmental disorders. However, the particular mechanisms of Al neurotoxicity and their role in Al-associated neurological disorders are still debatable. The neurotoxic effect of Al exposure is mediated by its common toxic properties including prooxidant, proinflammatory, proapoptotic activity that are reported for a variety of cell lines and tissues, as well as more specific “neurotropic” effects namely interference with neurotransmitter metabolism and neuronal cytoskeleton. Although specific treatment of Al toxicity is not developed, Al chelation as well as compounds targeting molecular mechanisms of Al neurotoxicity (trace elements, polyphenols, phytoextracts, etc.) may be considered as therapeutic strategies to counteract Al neurotoxicity. However, further studies are required to unravel the particular role of Al in neurological diseases and specific treatment agents.

Original language	English (US)
Title of host publication	Neurotoxicity of Metals
Subtitle of host publication	Old Issues and New Developments
Editors	Michael Aschner, Lucio G. Costa, Lucio G. Costa
Publisher	Elsevier Inc.
Pages	1-34
Number of pages	34
ISBN (Print)	9780128237755
DOIs	https://doi.org/10.1016/bs.ant.2020.12.001
State	Published - Jan 2021

Publication series

Name	Advances in Neurotoxicology
Volume	5
ISSN (Electronic)	2468-7480

Keywords

Aluminum
Neuroinflammation, amyloid
Neurotransmission
Oxidative stress

ASJC Scopus subject areas

Neuroscience (miscellaneous)
Health, Toxicology and Mutagenesis

Access to Document

10.1016/bs.ant.2020.12.001

Cite this

Skalny, A. V., Aschner, M., Jiang, Y., Gluhcheva, Y. G., Tizabi, Y., Lobinski, R., & Tinkov, A. A. (2021). Molecular mechanisms of aluminum neurotoxicity: Update on adverse effects and therapeutic strategies. In M. Aschner, L. G. Costa, & L. G. Costa (Eds.), Neurotoxicity of Metals: Old Issues and New Developments (pp. 1-34). (Advances in Neurotoxicology; Vol. 5). Elsevier Inc.. https://doi.org/10.1016/bs.ant.2020.12.001

Molecular mechanisms of aluminum neurotoxicity: Update on adverse effects and therapeutic strategies. / Skalny, Anatoly V.; Aschner, Michael; Jiang, Yueming et al.
Neurotoxicity of Metals: Old Issues and New Developments. ed. / Michael Aschner; Lucio G. Costa; Lucio G. Costa. Elsevier Inc., 2021. p. 1-34 (Advances in Neurotoxicology; Vol. 5).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Skalny, AV, Aschner, M, Jiang, Y, Gluhcheva, YG, Tizabi, Y, Lobinski, R & Tinkov, AA 2021, Molecular mechanisms of aluminum neurotoxicity: Update on adverse effects and therapeutic strategies. in M Aschner, LG Costa & LG Costa (eds), Neurotoxicity of Metals: Old Issues and New Developments. Advances in Neurotoxicology, vol. 5, Elsevier Inc., pp. 1-34. https://doi.org/10.1016/bs.ant.2020.12.001

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title = "Molecular mechanisms of aluminum neurotoxicity: Update on adverse effects and therapeutic strategies",

abstract = "Recent studies have demonstrated that brain may be considered as the target for aluminium (Al) toxicity, resulting in development of neurodegenerative and neurodevelopmental disorders. However, the particular mechanisms of Al neurotoxicity and their role in Al-associated neurological disorders are still debatable. The neurotoxic effect of Al exposure is mediated by its common toxic properties including prooxidant, proinflammatory, proapoptotic activity that are reported for a variety of cell lines and tissues, as well as more specific “neurotropic” effects namely interference with neurotransmitter metabolism and neuronal cytoskeleton. Although specific treatment of Al toxicity is not developed, Al chelation as well as compounds targeting molecular mechanisms of Al neurotoxicity (trace elements, polyphenols, phytoextracts, etc.) may be considered as therapeutic strategies to counteract Al neurotoxicity. However, further studies are required to unravel the particular role of Al in neurological diseases and specific treatment agents.",

keywords = "Aluminum, Neuroinflammation, amyloid, Neurotransmission, Oxidative stress",

author = "Skalny, {Anatoly V.} and Michael Aschner and Yueming Jiang and Gluhcheva, {Yordanka G.} and Yousef Tizabi and Ryszard Lobinski and Tinkov, {Alexey A.}",

note = "Funding Information: The study was performed with the support of the Russian Ministry of Science and Higher Education, Project No. 0856-2020-0008. M.A. was supported in part by grants from the National Institute of Environmental Health Sciences (NIEHS) R01ES07331 and R01ES10563. Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",

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N1 - Funding Information: The study was performed with the support of the Russian Ministry of Science and Higher Education, Project No. 0856-2020-0008. M.A. was supported in part by grants from the National Institute of Environmental Health Sciences (NIEHS) R01ES07331 and R01ES10563. Publisher Copyright: © 2021 Elsevier Inc.

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N2 - Recent studies have demonstrated that brain may be considered as the target for aluminium (Al) toxicity, resulting in development of neurodegenerative and neurodevelopmental disorders. However, the particular mechanisms of Al neurotoxicity and their role in Al-associated neurological disorders are still debatable. The neurotoxic effect of Al exposure is mediated by its common toxic properties including prooxidant, proinflammatory, proapoptotic activity that are reported for a variety of cell lines and tissues, as well as more specific “neurotropic” effects namely interference with neurotransmitter metabolism and neuronal cytoskeleton. Although specific treatment of Al toxicity is not developed, Al chelation as well as compounds targeting molecular mechanisms of Al neurotoxicity (trace elements, polyphenols, phytoextracts, etc.) may be considered as therapeutic strategies to counteract Al neurotoxicity. However, further studies are required to unravel the particular role of Al in neurological diseases and specific treatment agents.

AB - Recent studies have demonstrated that brain may be considered as the target for aluminium (Al) toxicity, resulting in development of neurodegenerative and neurodevelopmental disorders. However, the particular mechanisms of Al neurotoxicity and their role in Al-associated neurological disorders are still debatable. The neurotoxic effect of Al exposure is mediated by its common toxic properties including prooxidant, proinflammatory, proapoptotic activity that are reported for a variety of cell lines and tissues, as well as more specific “neurotropic” effects namely interference with neurotransmitter metabolism and neuronal cytoskeleton. Although specific treatment of Al toxicity is not developed, Al chelation as well as compounds targeting molecular mechanisms of Al neurotoxicity (trace elements, polyphenols, phytoextracts, etc.) may be considered as therapeutic strategies to counteract Al neurotoxicity. However, further studies are required to unravel the particular role of Al in neurological diseases and specific treatment agents.

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Molecular mechanisms of aluminum neurotoxicity: Update on adverse effects and therapeutic strategies

Abstract

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Keywords

ASJC Scopus subject areas

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