Molecular linkages between diabetes and Alzheimer's disease

Current scenario and future prospects

Tanveer A. Dar, Ishfaq A. Sheikh, Showkat A. Ganie, Riyasat Ali, Laishram R. Singh, Siew Hua Gan, Mohammad A. Kamal, Mohammad A. Zargar

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

After the revolutionary Rotterdam study that suggested there was an increased risk of developing Alzheimer's disease (AD) in patients with type-2 diabetes mellitus (T2DM), a number of studies have provided direct evidence for the linkage between AD and T2DM. In recent years, AD is considered as a neuroendocrine disorder, also referred as type-3 diabetes. There is a growing list of evidence to suggest that, in addition to impaired insulin signaling, there are a number of additional factors that may act as mechanistic links between AD and T2DM. These factors mainly include hypercholesterolemia, dyslipidemia, hypercystinemia, inflammation, impaired insulin signaling and impaired central nervous response to the adipose tissue-derived hormone leptin. Increased cholesterol plays a crucial role in the abnormal metabolism of the amyloid precursor protein, leading to the accumulation of β-amyloid. In addition to impaired insulin signaling, diabetes has been found to accelerate the appearance of cerebrovascular inflammation and β-amyloid peptide (Aβ) deposition. Increased oxidative stress and production of advanced glycation end products are other probable marker linkages. However, the details of many of these molecular links still require extensive investigation. It is possible that a number of common molecular linkages exist between T2DM and AD. Understanding and analyzing the various molecular linkages between AD and T2DM may shed light on new tools that can be used for the early diagnosis and treatment of AD and also accelerate the identification of T2DM patients who are at high risk of AD.

Original languageEnglish (US)
Pages (from-to)290-298
Number of pages9
JournalCNS and Neurological Disorders - Drug Targets
Volume13
Issue number2
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Fingerprint

Type 2 Diabetes Mellitus
Alzheimer Disease
Insulin
Amyloid
Inflammation
Advanced Glycosylation End Products
Amyloid beta-Protein Precursor
Dyslipidemias
Leptin
Hypercholesterolemia
Adipose Tissue
Early Diagnosis
Oxidative Stress
Cholesterol
Hormones
Alzheimer disease type 2

Keywords

  • Acetylcholine
  • Alzheimer's diseases
  • Amyloid peptide
  • Conformational diseases
  • Diabetes
  • Inflammation
  • Insulin resistance
  • Mitochondrial dysfunction
  • Oxidative stress
  • Telomere shortening

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pharmacology

Cite this

Molecular linkages between diabetes and Alzheimer's disease : Current scenario and future prospects. / Dar, Tanveer A.; Sheikh, Ishfaq A.; Ganie, Showkat A.; Ali, Riyasat; Singh, Laishram R.; Gan, Siew Hua; Kamal, Mohammad A.; Zargar, Mohammad A.

In: CNS and Neurological Disorders - Drug Targets, Vol. 13, No. 2, 01.01.2014, p. 290-298.

Research output: Contribution to journalArticle

Dar, Tanveer A. ; Sheikh, Ishfaq A. ; Ganie, Showkat A. ; Ali, Riyasat ; Singh, Laishram R. ; Gan, Siew Hua ; Kamal, Mohammad A. ; Zargar, Mohammad A. / Molecular linkages between diabetes and Alzheimer's disease : Current scenario and future prospects. In: CNS and Neurological Disorders - Drug Targets. 2014 ; Vol. 13, No. 2. pp. 290-298.
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