Molecular evolution and genetics of the Saitohin gene and tau haplotype in Alzheimer's disease and argyrophilic grain disease

Chris Conrad, Cintia Vianna, Christian Schultz, Dietmar R. Thal, Estifanos Ghebremedhin, Jack Lenz, Heiko Braak, Peter Davies

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

A single nucleotide polymorphism that results in an amino acid change (Q7R) has been identified in the Saitohin (STH) gene and was initially found to be over-represented in the homozygous state in subjects with late-onset Alzheimer's disease (AD). More extensive studies provide limited support for the association with AD, but confirm an association of the Q allele with progressive supranuclear palsy and argyrophilic grain disease. A homologous sequence was found in the appropriate location of the rat and mouse tau genes, but there was no open reading frame allowing STH expression in these species, suggesting relatively recent evolution of this gene. In some non-human primates, the STH gene was identified, and this was found to differ from the human gene at two of 128 amino acids. All primates in which the STH gene was identified were homozygous for the R allele of STH, suggesting this is the ancestral allele. This observation was surprising, in that the Q allele is more common in human populations, and raises the possibility that natural selection has operated to favor individuals carrying this allele. The STH polymorphism is part of the tau gene haplotype, of which two major variants exist in human populations, the Q being part of the H1 haplotype and the R part of the H2 haplotype. More detailed studies confirm the H2 haplotype to be the ancestral tau gene. This situation is reminiscent of the evolution of the apolipoprotein (ApoE) gene, another locus that is potentially important for the risk of development of AD.

Original languageEnglish (US)
Pages (from-to)179-188
Number of pages10
JournalJournal of Neurochemistry
Volume89
Issue number1
StatePublished - Apr 2004

Fingerprint

Molecular Evolution
Haplotypes
Molecular Biology
Alzheimer Disease
Genes
Alleles
Polymorphism
Primates
Progressive Supranuclear Palsy
Genetics
Amino Acids
Apolipoproteins
Genetic Selection
Sequence Homology
Population
Open Reading Frames
Single Nucleotide Polymorphism
Rats
Nucleotides

Keywords

  • Apolipoprotein E
  • Evolution
  • Saitohin
  • Tau

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

Conrad, C., Vianna, C., Schultz, C., Thal, D. R., Ghebremedhin, E., Lenz, J., ... Davies, P. (2004). Molecular evolution and genetics of the Saitohin gene and tau haplotype in Alzheimer's disease and argyrophilic grain disease. Journal of Neurochemistry, 89(1), 179-188.

Molecular evolution and genetics of the Saitohin gene and tau haplotype in Alzheimer's disease and argyrophilic grain disease. / Conrad, Chris; Vianna, Cintia; Schultz, Christian; Thal, Dietmar R.; Ghebremedhin, Estifanos; Lenz, Jack; Braak, Heiko; Davies, Peter.

In: Journal of Neurochemistry, Vol. 89, No. 1, 04.2004, p. 179-188.

Research output: Contribution to journalArticle

Conrad, C, Vianna, C, Schultz, C, Thal, DR, Ghebremedhin, E, Lenz, J, Braak, H & Davies, P 2004, 'Molecular evolution and genetics of the Saitohin gene and tau haplotype in Alzheimer's disease and argyrophilic grain disease', Journal of Neurochemistry, vol. 89, no. 1, pp. 179-188.
Conrad, Chris ; Vianna, Cintia ; Schultz, Christian ; Thal, Dietmar R. ; Ghebremedhin, Estifanos ; Lenz, Jack ; Braak, Heiko ; Davies, Peter. / Molecular evolution and genetics of the Saitohin gene and tau haplotype in Alzheimer's disease and argyrophilic grain disease. In: Journal of Neurochemistry. 2004 ; Vol. 89, No. 1. pp. 179-188.
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