Molecular dissection of dopamine receptor signaling

Noboru Hiroi, Ana B. Martín, Cristina Grande, Israel Alberti, Alicia Rivera, Rosario Moratalla

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

The use of genetically engineered mice has provided substantial new insights into the functional organization of the striatum. Increasing evidence suggests that specific genes expressed within the striatum contribute to its functional activity. We studied the dopamine (DA) D1 receptor gene and one of its downstream targets, the transcription factor c-Fos. We have evaluated the functional interaction between the D1 and D2 DA receptor subtypes at the cellular and behavioral levels. Our results show that haloperidol, a DA D2-class receptor antagonist, activates c-Fos predominantly in enkephalin-positive striatal neurons, which project to the globus pallidus and are thought to mediate motor inhibition. Deletion of the DA D1 receptor increased the responsiveness of enkephalin neurons to haloperidol, in that haloperidol-induced increases in c-Fos and catalepsy were enhanced in D1 receptor knockout mice. These results suggest a functionally opposing role of the D1 receptor against the D2 DA-class receptors in the striatum.

Original languageEnglish (US)
Pages (from-to)237-242
Number of pages6
JournalJournal of Chemical Neuroanatomy
Volume23
Issue number4
DOIs
StatePublished - Jun 19 2002

Keywords

  • Catalepsy
  • D1
  • D2
  • Enkephalin
  • Fos
  • Haloperidol

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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    Hiroi, N., Martín, A. B., Grande, C., Alberti, I., Rivera, A., & Moratalla, R. (2002). Molecular dissection of dopamine receptor signaling. Journal of Chemical Neuroanatomy, 23(4), 237-242. https://doi.org/10.1016/S0891-0618(02)00010-8