Abstract
Pancreatic neoplasms, including ductal adenocarcinoma, solid pseudopapillary neoplasm, pancreatic endocrine neoplasms, acinar cell carcinoma, and pancreatoblastoma, are associated with different genetic abnormalities. Hepatic adenomas with beta-catenin exon 3 mutation are associated with a high risk of malignancy. Hepatic adenoma with arginosuccinate synthetase 1 expression or sonic hedgehog mutations are associated with a risk of bleeding. Hepatocellular carcinoma and choangiocarcinoma display heterogeneity at both morphologic and molecular levels Cholangiocellular carcinoma is most commonly associated with IDH 1/2 mutations.
Original language | English (US) |
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Title of host publication | Clinics in Laboratory Medicine |
Editors | Louis Mansur, Bernard Riemer, David McClintock |
Publisher | W.B. Saunders |
Pages | 367-384 |
Number of pages | 18 |
Volume | 38 |
Edition | 2 |
ISBN (Print) | 9780323610728 |
DOIs | |
State | Published - Jun 2018 |
Externally published | Yes |
Keywords
- Cell free nucleic acid
- Cholangiocarcinoma
- Hepatic adenoma
- Hepatocellular carcinoma
- Liver
- Molecular diagnostics
- Pancreatic neoplasms
ASJC Scopus subject areas
- Clinical Biochemistry
- Biochemistry, medical