Molecular Diagnostics in the Neoplasms of the Pancreas, Liver, Gallbladder, and Extrahepatic Biliary Tract: 2018 Update

Lei Zhang, Martin H. Bluth, Amarpreet Bhalla

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Pancreatic neoplasms, including ductal adenocarcinoma, solid pseudopapillary neoplasm, pancreatic endocrine neoplasms, acinar cell carcinoma, and pancreatoblastoma, are associated with different genetic abnormalities. Hepatic adenomas with beta-catenin exon 3 mutation are associated with a high risk of malignancy. Hepatic adenoma with arginosuccinate synthetase 1 expression or sonic hedgehog mutations are associated with a risk of bleeding. Hepatocellular carcinoma and choangiocarcinoma display heterogeneity at both morphologic and molecular levels Cholangiocellular carcinoma is most commonly associated with IDH 1/2 mutations.

Original languageEnglish (US)
Title of host publicationClinics in Laboratory Medicine
EditorsLouis Mansur, Bernard Riemer, David McClintock
PublisherW.B. Saunders
Pages367-384
Number of pages18
Volume38
Edition2
ISBN (Print)9780323610728
DOIs
StatePublished - Jun 2018
Externally publishedYes

Keywords

  • Cell free nucleic acid
  • Cholangiocarcinoma
  • Hepatic adenoma
  • Hepatocellular carcinoma
  • Liver
  • Molecular diagnostics
  • Pancreatic neoplasms

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

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    Zhang, L., Bluth, M. H., & Bhalla, A. (2018). Molecular Diagnostics in the Neoplasms of the Pancreas, Liver, Gallbladder, and Extrahepatic Biliary Tract: 2018 Update. In L. Mansur, B. Riemer, & D. McClintock (Eds.), Clinics in Laboratory Medicine (2 ed., Vol. 38, pp. 367-384). W.B. Saunders. https://doi.org/10.1016/j.cll.2018.03.003