Molecular Diagnostics in Esophageal and Gastric Neoplasms: 2018 Update

Muhammad Zulfiqar, Martin H. Bluth, Amarpreet Bhalla

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Citations (Scopus)

Abstract

Esophageal cancer (EC) is rapidly increasing in incidence in the United States. Genetic changes associated with the development of EC involve the p16, p53, and APC genes. Human epidermal growth factor 2 (HER-2) overexpression is seen in gastroesophageal junction carcinoma and a subset gastric carcinoma (GC). Interestingly, up to 50% cases of GC are related to Helicobacter pylori infection and up to 16% are related to EBV infection. Microsatellite instability is observed in up to 39% of GC and cell free nucleic acid analysis provides additional opportunities for diagnosis and prognosis of disease.

Original languageEnglish (US)
Title of host publicationClinics in Laboratory Medicine
EditorsLouis Mansur, Bernard Riemer, David McClintock
PublisherW.B. Saunders
Pages357-365
Number of pages9
Volume38
Edition2
ISBN (Print)9780323610728
DOIs
StatePublished - Jun 2018
Externally publishedYes

Fingerprint

Molecular Pathology
Esophageal Neoplasms
Epidermal Growth Factor
Microsatellite Repeats
Nucleic Acids
Stomach Neoplasms
Genes
Carcinoma
Stomach
APC Genes
p16 Genes
Esophagogastric Junction
Microsatellite Instability
Epstein-Barr Virus Infections
p53 Genes
Helicobacter Infections
Helicobacter pylori
Incidence

Keywords

  • Adenocarcinoma
  • Esophagus
  • Gastric carcinoma
  • HER-2
  • Molecular genetics
  • Next-generation sequencing
  • Squamous cell carcinoma
  • Trastuzumab

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Zulfiqar, M., Bluth, M. H., & Bhalla, A. (2018). Molecular Diagnostics in Esophageal and Gastric Neoplasms: 2018 Update. In L. Mansur, B. Riemer, & D. McClintock (Eds.), Clinics in Laboratory Medicine (2 ed., Vol. 38, pp. 357-365). W.B. Saunders. https://doi.org/10.1016/j.cll.2018.02.009

Molecular Diagnostics in Esophageal and Gastric Neoplasms : 2018 Update. / Zulfiqar, Muhammad; Bluth, Martin H.; Bhalla, Amarpreet.

Clinics in Laboratory Medicine. ed. / Louis Mansur; Bernard Riemer; David McClintock. Vol. 38 2. ed. W.B. Saunders, 2018. p. 357-365.

Research output: Chapter in Book/Report/Conference proceedingChapter

Zulfiqar, M, Bluth, MH & Bhalla, A 2018, Molecular Diagnostics in Esophageal and Gastric Neoplasms: 2018 Update. in L Mansur, B Riemer & D McClintock (eds), Clinics in Laboratory Medicine. 2 edn, vol. 38, W.B. Saunders, pp. 357-365. https://doi.org/10.1016/j.cll.2018.02.009
Zulfiqar M, Bluth MH, Bhalla A. Molecular Diagnostics in Esophageal and Gastric Neoplasms: 2018 Update. In Mansur L, Riemer B, McClintock D, editors, Clinics in Laboratory Medicine. 2 ed. Vol. 38. W.B. Saunders. 2018. p. 357-365 https://doi.org/10.1016/j.cll.2018.02.009
Zulfiqar, Muhammad ; Bluth, Martin H. ; Bhalla, Amarpreet. / Molecular Diagnostics in Esophageal and Gastric Neoplasms : 2018 Update. Clinics in Laboratory Medicine. editor / Louis Mansur ; Bernard Riemer ; David McClintock. Vol. 38 2. ed. W.B. Saunders, 2018. pp. 357-365
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