Molecular Diagnostics in Esophageal and Gastric Neoplasms: 2018 Update

Muhammad Zulfiqar, Martin H. Bluth, Amarpreet Bhalla

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations

Abstract

Esophageal cancer (EC) is rapidly increasing in incidence in the United States. Genetic changes associated with the development of EC involve the p16, p53, and APC genes. Human epidermal growth factor 2 (HER-2) overexpression is seen in gastroesophageal junction carcinoma and a subset gastric carcinoma (GC). Interestingly, up to 50% cases of GC are related to Helicobacter pylori infection and up to 16% are related to EBV infection. Microsatellite instability is observed in up to 39% of GC and cell free nucleic acid analysis provides additional opportunities for diagnosis and prognosis of disease.

Original languageEnglish (US)
Title of host publicationClinics in Laboratory Medicine
EditorsLouis Mansur, Bernard Riemer, David McClintock
PublisherW.B. Saunders
Pages357-365
Number of pages9
Volume38
Edition2
ISBN (Print)9780323610728
DOIs
StatePublished - Jun 2018
Externally publishedYes

Keywords

  • Adenocarcinoma
  • Esophagus
  • Gastric carcinoma
  • HER-2
  • Molecular genetics
  • Next-generation sequencing
  • Squamous cell carcinoma
  • Trastuzumab

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

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  • Cite this

    Zulfiqar, M., Bluth, M. H., & Bhalla, A. (2018). Molecular Diagnostics in Esophageal and Gastric Neoplasms: 2018 Update. In L. Mansur, B. Riemer, & D. McClintock (Eds.), Clinics in Laboratory Medicine (2 ed., Vol. 38, pp. 357-365). W.B. Saunders. https://doi.org/10.1016/j.cll.2018.02.009