Molecular Diagnostics in Esophageal and Gastric Neoplasms: 2018 Update

Muhammad Zulfiqar; Martin H. Bluth; Amarpreet Bhalla

doi:10.1016/j.cll.2018.02.009

Molecular Diagnostics in Esophageal and Gastric Neoplasms: 2018 Update

Muhammad Zulfiqar, Martin H. Bluth, Amarpreet Bhalla

Research output: Chapter in Book/Report/Conference proceeding › Chapter

8 Scopus citations

Abstract

Esophageal cancer (EC) is rapidly increasing in incidence in the United States. Genetic changes associated with the development of EC involve the p16, p53, and APC genes. Human epidermal growth factor 2 (HER-2) overexpression is seen in gastroesophageal junction carcinoma and a subset gastric carcinoma (GC). Interestingly, up to 50% cases of GC are related to Helicobacter pylori infection and up to 16% are related to EBV infection. Microsatellite instability is observed in up to 39% of GC and cell free nucleic acid analysis provides additional opportunities for diagnosis and prognosis of disease.

Original language	English (US)
Title of host publication	Clinics in Laboratory Medicine
Editors	Louis Mansur, Bernard Riemer, David McClintock
Publisher	W.B. Saunders
Pages	357-365
Number of pages	9
Volume	38
Edition	2
ISBN (Print)	9780323610728
DOIs	https://doi.org/10.1016/j.cll.2018.02.009
State	Published - Jun 2018
Externally published	Yes

Keywords

Adenocarcinoma
Esophagus
Gastric carcinoma
HER-2
Molecular genetics
Next-generation sequencing
Squamous cell carcinoma
Trastuzumab

ASJC Scopus subject areas

Clinical Biochemistry
Biochemistry, medical

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.cll.2018.02.009

Cite this

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title = "Molecular Diagnostics in Esophageal and Gastric Neoplasms: 2018 Update",

abstract = "Esophageal cancer (EC) is rapidly increasing in incidence in the United States. Genetic changes associated with the development of EC involve the p16, p53, and APC genes. Human epidermal growth factor 2 (HER-2) overexpression is seen in gastroesophageal junction carcinoma and a subset gastric carcinoma (GC). Interestingly, up to 50% cases of GC are related to Helicobacter pylori infection and up to 16% are related to EBV infection. Microsatellite instability is observed in up to 39% of GC and cell free nucleic acid analysis provides additional opportunities for diagnosis and prognosis of disease.",

keywords = "Adenocarcinoma, Esophagus, Gastric carcinoma, HER-2, Molecular genetics, Next-generation sequencing, Squamous cell carcinoma, Trastuzumab",

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year = "2018",

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language = "English (US)",

isbn = "9780323610728",

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T1 - Molecular Diagnostics in Esophageal and Gastric Neoplasms

T2 - 2018 Update

AU - Zulfiqar, Muhammad

AU - Bluth, Martin H.

AU - Bhalla, Amarpreet

PY - 2018/6

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N2 - Esophageal cancer (EC) is rapidly increasing in incidence in the United States. Genetic changes associated with the development of EC involve the p16, p53, and APC genes. Human epidermal growth factor 2 (HER-2) overexpression is seen in gastroesophageal junction carcinoma and a subset gastric carcinoma (GC). Interestingly, up to 50% cases of GC are related to Helicobacter pylori infection and up to 16% are related to EBV infection. Microsatellite instability is observed in up to 39% of GC and cell free nucleic acid analysis provides additional opportunities for diagnosis and prognosis of disease.

AB - Esophageal cancer (EC) is rapidly increasing in incidence in the United States. Genetic changes associated with the development of EC involve the p16, p53, and APC genes. Human epidermal growth factor 2 (HER-2) overexpression is seen in gastroesophageal junction carcinoma and a subset gastric carcinoma (GC). Interestingly, up to 50% cases of GC are related to Helicobacter pylori infection and up to 16% are related to EBV infection. Microsatellite instability is observed in up to 39% of GC and cell free nucleic acid analysis provides additional opportunities for diagnosis and prognosis of disease.

KW - Adenocarcinoma

KW - Esophagus

KW - Gastric carcinoma

KW - HER-2

KW - Molecular genetics

KW - Next-generation sequencing

KW - Squamous cell carcinoma

KW - Trastuzumab

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ER -

Molecular Diagnostics in Esophageal and Gastric Neoplasms: 2018 Update

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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