Molecular diagnostics in esophageal and gastric neoplasms

Muhammad Zulfiqar, Amarpreet Bhalla, Michael Weindel, Vinod B. Shidham

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

Esophageal carcinoma is the most rapidly increasing tumor in incidence in the United States. It has an established association with a precursor lesion (Barrett esophagus). Gastric carcinoma (GC) is the second leading cause of cancer death in the world. The prognosis for patients with advanced stage GC and esophageal carcinoma is poor. Human epidermal growth factor 2 (HER-2) overexpression is seen in gastroesophageal junction carcinoma and a subset of GC. HER-2 overexpressing tumors are eligible for HER-2 targeted therapies, which lead to a better survival in these patients.

Original languageEnglish (US)
Pages (from-to)867-873
Number of pages7
JournalClinics in Laboratory Medicine
Volume33
Issue number4
DOIs
Publication statusPublished - Dec 1 2013
Externally publishedYes

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Keywords

  • Adenocarcinoma
  • Esophagus
  • Gastric carcinoma
  • HER-2
  • Molecular genetics
  • Squamous cell carcinoma
  • Trastuzumab

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

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