TY - JOUR
T1 - Molecular determinants of human red/green color discrimination
AU - Asenjo, Ana B.
AU - Rim, Jeanne
AU - Oprian, Daniel D.
N1 - Funding Information:
This work was supported by National Institutes of Health grant EY09514. J. R. is a trainee on National Institutes of Health training grant 5T32 GM0796.
PY - 1994/5
Y1 - 1994/5
N2 - The human red and green color vision pigments are identical at all but 15 of their 364 amino acids, and yet their absorption maxima differ by 31 nm. In an extensive mutagenesis study, including a set of 28 chimeric proteins modeled after pigments in the color-deficient human population and an additional 30 single and multiple point mutants, the spectral difference between these 2 pigments is shown to be determined by 7 and only 7 amino acid residues. In going from the red pigment to the green pigment, the 7 residues are Ser116 → Tyr, Ser180 → Ala, Ile230 → Thr, Ala233 → Ser, Tyr277 → Phe, Thr285 → Ala, and Tyr309 → Phe.
AB - The human red and green color vision pigments are identical at all but 15 of their 364 amino acids, and yet their absorption maxima differ by 31 nm. In an extensive mutagenesis study, including a set of 28 chimeric proteins modeled after pigments in the color-deficient human population and an additional 30 single and multiple point mutants, the spectral difference between these 2 pigments is shown to be determined by 7 and only 7 amino acid residues. In going from the red pigment to the green pigment, the 7 residues are Ser116 → Tyr, Ser180 → Ala, Ile230 → Thr, Ala233 → Ser, Tyr277 → Phe, Thr285 → Ala, and Tyr309 → Phe.
UR - http://www.scopus.com/inward/record.url?scp=0028289475&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028289475&partnerID=8YFLogxK
U2 - 10.1016/0896-6273(94)90320-4
DO - 10.1016/0896-6273(94)90320-4
M3 - Article
C2 - 8185948
AN - SCOPUS:0028289475
SN - 0896-6273
VL - 12
SP - 1131
EP - 1138
JO - Neuron
JF - Neuron
IS - 5
ER -